Abstract
Fluid bed granulation is a complex, multi-phase, multi-component unit operation often used in the pharmaceutical industry. Various attributes such as particle morphology, size, porosity, wettability, and binder viscosity play key roles in determining the overall size and composition of the granules that are produced. In this paper, we examine the interaction between binder addition and particle morphology and its impact on granule growth. A multi-dimensional population balance model that tracks the evolution of granule size and binder content distribution is used. A constant-number Monte Carlo algorithm that has been adapted to accommodate continuous processes such as the continuous addition of binder to a system is employed to solve the population balance. Simulation results are then compared with experimental results.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-220 |
| Number of pages | 10 |
| Journal | Powder Technology |
| Volume | 236 |
| DOIs | |
| State | Published - Feb 1 2013 |
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All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)
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Multi-component population balance modeling of granulation with continuous addition of binder. / Marshall, Carl L.; Rajniak, Pavol; Matsoukas, Themis.
In: Powder Technology, Vol. 236, 01.02.2013, p. 211-220.Research output: Contribution to journal › Article
TY - JOUR
T1 - Multi-component population balance modeling of granulation with continuous addition of binder
AU - Marshall, Carl L.
AU - Rajniak, Pavol
AU - Matsoukas, Themis
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Fluid bed granulation is a complex, multi-phase, multi-component unit operation often used in the pharmaceutical industry. Various attributes such as particle morphology, size, porosity, wettability, and binder viscosity play key roles in determining the overall size and composition of the granules that are produced. In this paper, we examine the interaction between binder addition and particle morphology and its impact on granule growth. A multi-dimensional population balance model that tracks the evolution of granule size and binder content distribution is used. A constant-number Monte Carlo algorithm that has been adapted to accommodate continuous processes such as the continuous addition of binder to a system is employed to solve the population balance. Simulation results are then compared with experimental results.
AB - Fluid bed granulation is a complex, multi-phase, multi-component unit operation often used in the pharmaceutical industry. Various attributes such as particle morphology, size, porosity, wettability, and binder viscosity play key roles in determining the overall size and composition of the granules that are produced. In this paper, we examine the interaction between binder addition and particle morphology and its impact on granule growth. A multi-dimensional population balance model that tracks the evolution of granule size and binder content distribution is used. A constant-number Monte Carlo algorithm that has been adapted to accommodate continuous processes such as the continuous addition of binder to a system is employed to solve the population balance. Simulation results are then compared with experimental results.
UR - http://www.scopus.com/inward/record.url?scp=84873731672&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873731672&partnerID=8YFLogxK
U2 - 10.1016/j.powtec.2012.01.027
DO - 10.1016/j.powtec.2012.01.027
M3 - Article
AN - SCOPUS:84873731672
VL - 236
SP - 211
EP - 220
JO - Powder Technology
JF - Powder Technology
SN - 0032-5910
ER -