Multi-component population balance modeling of granulation with continuous addition of binder

Carl L. Marshall, Pavol Rajniak, Themis Matsoukas

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Fluid bed granulation is a complex, multi-phase, multi-component unit operation often used in the pharmaceutical industry. Various attributes such as particle morphology, size, porosity, wettability, and binder viscosity play key roles in determining the overall size and composition of the granules that are produced. In this paper, we examine the interaction between binder addition and particle morphology and its impact on granule growth. A multi-dimensional population balance model that tracks the evolution of granule size and binder content distribution is used. A constant-number Monte Carlo algorithm that has been adapted to accommodate continuous processes such as the continuous addition of binder to a system is employed to solve the population balance. Simulation results are then compared with experimental results.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalPowder Technology
Volume236
DOIs
StatePublished - Feb 1 2013

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Granulation
Binders
Drug products
Wetting
Porosity
Viscosity
Fluids
Chemical analysis
Pharmaceutical Preparations
Industry

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cite this

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Multi-component population balance modeling of granulation with continuous addition of binder. / Marshall, Carl L.; Rajniak, Pavol; Matsoukas, Themis.

In: Powder Technology, Vol. 236, 01.02.2013, p. 211-220.

Research output: Contribution to journalArticle

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