1 Citation (Scopus)

Abstract

Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cell-scale interactions are explicitly resolved. To be biologically representative, these models account for some or all of: (1) fluid dynamics of the carrier flow, (2) structural dynamics of the cells and vessel walls, (3) interaction and transport biochemistry, and, (4) methods for scaling to physiologically representative numbers of cells. In this article, our interest is the modelling of the tumour micro-environment. We review the broader area of cell-scale resolving blood flow modelling, while focusing on the particular interactions of tumour cells and white blood cells, known to play an important role in metastasis.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalDrug Discovery Today: Disease Models
Volume16
DOIs
StatePublished - Feb 2 2015

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Cell Communication
Computing Methodologies
Physics
Hydrodynamics
Biochemistry
Cell Wall
Blood Cells
Neoplasms
Leukocytes
Cell Count
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Cite this

@article{b568e6b592bf4be28416837bd8f02b11,
title = "Multi-scale biological and physical modelling of the tumour micro-environment",
abstract = "Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cell-scale interactions are explicitly resolved. To be biologically representative, these models account for some or all of: (1) fluid dynamics of the carrier flow, (2) structural dynamics of the cells and vessel walls, (3) interaction and transport biochemistry, and, (4) methods for scaling to physiologically representative numbers of cells. In this article, our interest is the modelling of the tumour micro-environment. We review the broader area of cell-scale resolving blood flow modelling, while focusing on the particular interactions of tumour cells and white blood cells, known to play an important role in metastasis.",
author = "Kunz, {Robert Francis} and Gaskin, {Byron J.} and Qunhua Li and Sam Davanloo-Tajbakhsh and Cheng Dong",
year = "2015",
month = "2",
day = "2",
doi = "10.1016/j.ddmod.2015.03.001",
language = "English (US)",
volume = "16",
pages = "7--15",
journal = "Drug Discovery Today: Disease Models",
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}

Multi-scale biological and physical modelling of the tumour micro-environment. / Kunz, Robert Francis; Gaskin, Byron J.; Li, Qunhua; Davanloo-Tajbakhsh, Sam; Dong, Cheng.

In: Drug Discovery Today: Disease Models, Vol. 16, 02.02.2015, p. 7-15.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Multi-scale biological and physical modelling of the tumour micro-environment

AU - Kunz, Robert Francis

AU - Gaskin, Byron J.

AU - Li, Qunhua

AU - Davanloo-Tajbakhsh, Sam

AU - Dong, Cheng

PY - 2015/2/2

Y1 - 2015/2/2

N2 - Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cell-scale interactions are explicitly resolved. To be biologically representative, these models account for some or all of: (1) fluid dynamics of the carrier flow, (2) structural dynamics of the cells and vessel walls, (3) interaction and transport biochemistry, and, (4) methods for scaling to physiologically representative numbers of cells. In this article, our interest is the modelling of the tumour micro-environment. We review the broader area of cell-scale resolving blood flow modelling, while focusing on the particular interactions of tumour cells and white blood cells, known to play an important role in metastasis.

AB - Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cell-scale interactions are explicitly resolved. To be biologically representative, these models account for some or all of: (1) fluid dynamics of the carrier flow, (2) structural dynamics of the cells and vessel walls, (3) interaction and transport biochemistry, and, (4) methods for scaling to physiologically representative numbers of cells. In this article, our interest is the modelling of the tumour micro-environment. We review the broader area of cell-scale resolving blood flow modelling, while focusing on the particular interactions of tumour cells and white blood cells, known to play an important role in metastasis.

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DO - 10.1016/j.ddmod.2015.03.001

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