Multicomponent Redox Catalysts for Reduction of Large Biological Molecules Using Molecular Hydrogen as the Reductant

Shuchi Chao, Richard A. Simon, Thomas E. Mallouk, Mark S. Wrighton

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

One-electron reduction of the large biological molecules horse heart cytochrome c, sperm whale myoglobin, and horseradish peroxidase using H2 as the reductant can be catalyzed by two-component, high surface area heterogeneous catalysts. The catalysts can be prepared by first functionalizing high surface area Si02 with a polycationic polymer into which is dispersed MCl4 2-(M = Pd, Pt). Reduction with H2 yields elemental Pd or Pt dispersed in the polymer. The particles are finally functionalized with a redox polymer derived from hydrolysis of Si(OR)3 groups of an N,N'-dialkyl-4,4'-bipyridinium- or from a cobalticenium-based monomer. The two components of the heterogeneous catalysts are the buried noble metal capable of activating the H2 and the redox polymer, which can equilibrate both with the noble metal and with the large biological molecule. Reduction of the large biological molecules in aqueous solution can be effected at room temperature and 1 atm H2 using the catalysts under conditions where the biological materials would not be reducible with H2 alone or when the noble metal alone would be used as the catalyst.

Original languageEnglish (US)
Pages (from-to)2270-2276
Number of pages7
JournalJournal of the American Chemical Society
Volume110
Issue number7
DOIs
StatePublished - Jan 1 1988

Fingerprint

Reducing Agents
Oxidation-Reduction
Hydrogen
Polymers
Precious metals
Catalysts
Molecules
Metals
Sperm Whale
Myoglobin
Horseradish Peroxidase
Cytochromes c
Horses
Hydrolysis
Biological materials
Electrons
Monomers
Temperature
Proteins

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Chao, Shuchi ; Simon, Richard A. ; Mallouk, Thomas E. ; Wrighton, Mark S. / Multicomponent Redox Catalysts for Reduction of Large Biological Molecules Using Molecular Hydrogen as the Reductant. In: Journal of the American Chemical Society. 1988 ; Vol. 110, No. 7. pp. 2270-2276.
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Multicomponent Redox Catalysts for Reduction of Large Biological Molecules Using Molecular Hydrogen as the Reductant. / Chao, Shuchi; Simon, Richard A.; Mallouk, Thomas E.; Wrighton, Mark S.

In: Journal of the American Chemical Society, Vol. 110, No. 7, 01.01.1988, p. 2270-2276.

Research output: Contribution to journalArticle

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