Multifactor dimensionality reduction

An analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies

Alison A. Motsinger, Marylyn Deriggi Ritchie

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

The detection of gene-gene and gene-environment interactions associated with complex human disease or pharmacogenomic endpoints is a difficult challenge for human geneticists. Unlike rare, Mendelian diseases that are associated with a single gene, most common diseases are caused by the non-linear interaction of numerous genetic and environmental variables. The dimensionality involved in the evaluation of combinations of many such variables quickly diminishes the usefulness of traditional, parametric statistical methods. Multifactor dimensionality reduction (MDR) is a novel and powerful statistical tool for detecting and modelling epistasis. MDR is a non-parametric and model-free approach that has been shown to have reasonable power to detect epistasis in both theoretical and empirical studies. MDR has detected inter-actions in diseases such as sporadic breast cancer, multiple sclerosis and essential hypertension. As this method is more frequently applied, and was gained acceptance in the study of human disease and pharmacogenomics, it is becoming increasingly important that the implementation of the MDR approach is properly understood. As with all statistical methods, MDR is only powerful and useful when implemented correctly. Concerns regarding dataset structure, configuration parameters and the proper execution of permutation testing in reference to a particular dataset and configuration are essential to the method's effectiveness. The detection, characterisation and interpretation of gene-gene and gene-environment interactions are expected to improve the diagnosis, prevention and treatment of common human diseases. MDR can be a powerful tool in reaching these goals when used appropriately.

Original languageEnglish (US)
Pages (from-to)318-328
Number of pages11
JournalHuman genomics
Volume2
Issue number5
StatePublished - Mar 1 2006

Fingerprint

Multifactor Dimensionality Reduction
Medical Genetics
Genes
Gene-Environment Interaction
Pharmacogenetics
Rare Diseases
Multiple Sclerosis
Pharmacogenomic Testing
Theoretical Models
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery

Cite this

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Multifactor dimensionality reduction : An analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. / Motsinger, Alison A.; Ritchie, Marylyn Deriggi.

In: Human genomics, Vol. 2, No. 5, 01.03.2006, p. 318-328.

Research output: Contribution to journalReview article

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