Multimodal Amnesic Syndrome Following Bilateral Temporal and Basal Forebrain Damage

Antonio R. Damasio, Paul J. Eslinger, Hanna Damasio, Gary W. Van Hoesen, Steven Cornell

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

A 55-year-old right-handed man (patient DRB) had a major amnesic syndrome following extensive bilateral damage to the temporal lobe and basal forebrain, caused by herpes simplex encephalitis. His amnesia was both anterograde and retrograde. The retrograde amnesia spanned the five decades of his life, sparing only generic (semantic) material and shreds of previous experiences devoid of appropriate temporal and spatial placement. The anterograde amnesia encompassed both generic (semantic) and contextual (episodic) material. With the exception of preserved learning of a visuomotor skill, the patient did not show acquisition of any new information since his illness in 1975. Elementary perceptual, intellectual, and linguistic abilities remained intact. Because several anatomic and behavioral characteristics of this case are different from those of previously reported cases of amnesia, they may provide new insight into the neuroanatomic substrate of human memory.

Original languageEnglish (US)
Pages (from-to)252-259
Number of pages8
JournalArchives of Neurology
Volume42
Issue number3
DOIs
StatePublished - Mar 1985

Fingerprint

Amnesia
Semantics
Anterograde Amnesia
Retrograde Amnesia
Dichlororibofuranosylbenzimidazole
Herpes Simplex Encephalitis
Aptitude
Temporal Lobe
Linguistics
Learning
Basal Forebrain
Syndrome
Damage

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Damasio, Antonio R. ; Eslinger, Paul J. ; Damasio, Hanna ; Van Hoesen, Gary W. ; Cornell, Steven. / Multimodal Amnesic Syndrome Following Bilateral Temporal and Basal Forebrain Damage. In: Archives of Neurology. 1985 ; Vol. 42, No. 3. pp. 252-259.
@article{aa287a6ed06544a8a71dfcfe4cd2fe64,
title = "Multimodal Amnesic Syndrome Following Bilateral Temporal and Basal Forebrain Damage",
abstract = "A 55-year-old right-handed man (patient DRB) had a major amnesic syndrome following extensive bilateral damage to the temporal lobe and basal forebrain, caused by herpes simplex encephalitis. His amnesia was both anterograde and retrograde. The retrograde amnesia spanned the five decades of his life, sparing only generic (semantic) material and shreds of previous experiences devoid of appropriate temporal and spatial placement. The anterograde amnesia encompassed both generic (semantic) and contextual (episodic) material. With the exception of preserved learning of a visuomotor skill, the patient did not show acquisition of any new information since his illness in 1975. Elementary perceptual, intellectual, and linguistic abilities remained intact. Because several anatomic and behavioral characteristics of this case are different from those of previously reported cases of amnesia, they may provide new insight into the neuroanatomic substrate of human memory.",
author = "Damasio, {Antonio R.} and Eslinger, {Paul J.} and Hanna Damasio and {Van Hoesen}, {Gary W.} and Steven Cornell",
year = "1985",
month = "3",
doi = "10.1001/archneur.1985.04060030070012",
language = "English (US)",
volume = "42",
pages = "252--259",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "3",

}

Multimodal Amnesic Syndrome Following Bilateral Temporal and Basal Forebrain Damage. / Damasio, Antonio R.; Eslinger, Paul J.; Damasio, Hanna; Van Hoesen, Gary W.; Cornell, Steven.

In: Archives of Neurology, Vol. 42, No. 3, 03.1985, p. 252-259.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multimodal Amnesic Syndrome Following Bilateral Temporal and Basal Forebrain Damage

AU - Damasio, Antonio R.

AU - Eslinger, Paul J.

AU - Damasio, Hanna

AU - Van Hoesen, Gary W.

AU - Cornell, Steven

PY - 1985/3

Y1 - 1985/3

N2 - A 55-year-old right-handed man (patient DRB) had a major amnesic syndrome following extensive bilateral damage to the temporal lobe and basal forebrain, caused by herpes simplex encephalitis. His amnesia was both anterograde and retrograde. The retrograde amnesia spanned the five decades of his life, sparing only generic (semantic) material and shreds of previous experiences devoid of appropriate temporal and spatial placement. The anterograde amnesia encompassed both generic (semantic) and contextual (episodic) material. With the exception of preserved learning of a visuomotor skill, the patient did not show acquisition of any new information since his illness in 1975. Elementary perceptual, intellectual, and linguistic abilities remained intact. Because several anatomic and behavioral characteristics of this case are different from those of previously reported cases of amnesia, they may provide new insight into the neuroanatomic substrate of human memory.

AB - A 55-year-old right-handed man (patient DRB) had a major amnesic syndrome following extensive bilateral damage to the temporal lobe and basal forebrain, caused by herpes simplex encephalitis. His amnesia was both anterograde and retrograde. The retrograde amnesia spanned the five decades of his life, sparing only generic (semantic) material and shreds of previous experiences devoid of appropriate temporal and spatial placement. The anterograde amnesia encompassed both generic (semantic) and contextual (episodic) material. With the exception of preserved learning of a visuomotor skill, the patient did not show acquisition of any new information since his illness in 1975. Elementary perceptual, intellectual, and linguistic abilities remained intact. Because several anatomic and behavioral characteristics of this case are different from those of previously reported cases of amnesia, they may provide new insight into the neuroanatomic substrate of human memory.

UR - http://www.scopus.com/inward/record.url?scp=0021914366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021914366&partnerID=8YFLogxK

U2 - 10.1001/archneur.1985.04060030070012

DO - 10.1001/archneur.1985.04060030070012

M3 - Article

C2 - 3977656

AN - SCOPUS:0021914366

VL - 42

SP - 252

EP - 259

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 3

ER -