TY - JOUR
T1 - Multiorgan sensitivity to anticarcinogenesis by the organoselenium 1,4-phenylenebis(methylene)selenocyanate
AU - El-Bayoumy, K.
AU - Rao, C. V.
AU - Reddy, B. S.
N1 - Funding Information:
We thank Patricia Sellazzo for preparing and Ilse Hoffmann for editing the manuscript and the staff in the Research Animal Facility for handling and treatment of the animals. The work described in this report was supported by National Institutes of Health Grants CA-46589, CA-70972, and DE-13222. This work is dedicated to the memory of Dr. Larry Clark: a friend, a scientist and, above all, a human being. Address correspondence to Karam El-Bayoumy, Div. of Cancer Etiology and Prevention, American Health Foundation, 1 Dana Rd., Valhalla, NY 10595. E-mail: kelbayoumy@aol.com.
PY - 2001
Y1 - 2001
N2 - The data in this report clearly indicate that the form (structure) in which selenium is used is the most critical determinant of success in future clinical trials. Synthetic organoselenium compounds can be tailored to achieve greater chemopreventive efficacy with minimal toxic side effects by structural modifications. We demonstrated that 1,4-phenylenebis(methylene)selenocyanate is a powerful chemopreventive agent against the development of experimental colon, mammary, lung, and oral carcinogenesis. On the basis of metabolism studies of organoselenium compounds and those reported in the literature, our working hypothesis is that aromatic selenol intermediates are important entities in cancer chemoprevention. In addition, we suggest that 1,4-phenylenebis(methylene)selenocyanate not only serves as a chemopreventive agent, but it may be valuable in preventing metastatic diseases in future studies in the clinic.
AB - The data in this report clearly indicate that the form (structure) in which selenium is used is the most critical determinant of success in future clinical trials. Synthetic organoselenium compounds can be tailored to achieve greater chemopreventive efficacy with minimal toxic side effects by structural modifications. We demonstrated that 1,4-phenylenebis(methylene)selenocyanate is a powerful chemopreventive agent against the development of experimental colon, mammary, lung, and oral carcinogenesis. On the basis of metabolism studies of organoselenium compounds and those reported in the literature, our working hypothesis is that aromatic selenol intermediates are important entities in cancer chemoprevention. In addition, we suggest that 1,4-phenylenebis(methylene)selenocyanate not only serves as a chemopreventive agent, but it may be valuable in preventing metastatic diseases in future studies in the clinic.
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U2 - 10.1207/S15327914NC401_6
DO - 10.1207/S15327914NC401_6
M3 - Review article
C2 - 11799918
AN - SCOPUS:0035679736
VL - 40
SP - 18
EP - 27
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 1
ER -
