Multiple amphetamine injections reduce the release of ascorbic acid in the neostriatum of the rat

Katsuo Kamata, Robert L. Wilson, Kevin D. Alloway, George V. Rebec

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Voltammetric signals were recorded bilaterally with unmodified or electrochemically-modified carbon-fiber electrodes in the neostriatum of rats that sustained a unilateral depletion of dopamine by pretreatment with 6-hydroxydopamine. In both hemispheres, single daily injections of d-amphetamine (5.0 mg/kg or steadily increasing doses beginning with 6.0 mg/kg) for 6 consecutive days significantly reduced the rise in oxidation current produced by a challenge injection of 2.5 mg/kg d-amphetamine compared to the response obtained from saline-treated controls. Voltammetric scans indicated that the oxidized substance shared the electrochemical characteristics of ascorbic acid. It appears, therefore, that multiple amphetamine injections reduce the release of ascorbic acid in the neostriatum and that this effect does not depend on the integrity of dopaminergic neurons.

Original languageEnglish (US)
Pages (from-to)331-338
Number of pages8
JournalBrain research
Volume362
Issue number2
DOIs
StatePublished - Jan 8 1986

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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