Multiple cutaneous monoclonal B-cell proliferations as harbingers of systemic angioimmunoblastic T-cell lymphoma

Michael G. Bayerl, Jeannie Hennessy, William Christopher Ehmann, Adam Bagg, Lorraine Rosamilia, Loren E. Clarke

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We describe a 66-year-old man initially diagnosed with primary cutaneous marginal zone B-cell lymphoma who developed four additional monoclonal/monotypic B-cell lymphoid proliferations and a systemic angioimmunoblastic T-cell lymphoma over the course of 19 months. Through retrospective analysis, we identified the evolution of a T-cell clone within the background of clinically and pathologically dominant cutaneous B-cell tumors. In terms of clinical practice, this case supports that patients diagnosed with multiple clonal B-cell proliferation need thorough investigation and close clinical follow up to identify a coexistent or evolving systemic lymphoma, in particular, peripheral T-cell lymphomas of follicular T-helper cell type, such as angioimmunoblastic T-cell lymphoma. Biologically, this case offers unique insight into the interactions between B-cell and T-cell lineages in lymphoid neoplasia. Bayerl MG, Hennessy J, Ehmann WC, Bagg A, Rosamilia L, Clarke LE. Multiple cutaneous monoclonal B-cell proliferations as harbingers of systemic angioimmunoblastic T-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)777-786
Number of pages10
JournalJournal of Cutaneous Pathology
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2010

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T-Cell Lymphoma
B-Lymphocytes
Cell Proliferation
Skin
Peripheral T-Cell Lymphoma
T-Lymphocytes
Marginal Zone B-Cell Lymphoma
Cell Lineage
Helper-Inducer T-Lymphocytes
Lymphoma
Neoplasms
Clone Cells

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

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abstract = "We describe a 66-year-old man initially diagnosed with primary cutaneous marginal zone B-cell lymphoma who developed four additional monoclonal/monotypic B-cell lymphoid proliferations and a systemic angioimmunoblastic T-cell lymphoma over the course of 19 months. Through retrospective analysis, we identified the evolution of a T-cell clone within the background of clinically and pathologically dominant cutaneous B-cell tumors. In terms of clinical practice, this case supports that patients diagnosed with multiple clonal B-cell proliferation need thorough investigation and close clinical follow up to identify a coexistent or evolving systemic lymphoma, in particular, peripheral T-cell lymphomas of follicular T-helper cell type, such as angioimmunoblastic T-cell lymphoma. Biologically, this case offers unique insight into the interactions between B-cell and T-cell lineages in lymphoid neoplasia. Bayerl MG, Hennessy J, Ehmann WC, Bagg A, Rosamilia L, Clarke LE. Multiple cutaneous monoclonal B-cell proliferations as harbingers of systemic angioimmunoblastic T-cell lymphoma.",
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Multiple cutaneous monoclonal B-cell proliferations as harbingers of systemic angioimmunoblastic T-cell lymphoma. / Bayerl, Michael G.; Hennessy, Jeannie; Ehmann, William Christopher; Bagg, Adam; Rosamilia, Lorraine; Clarke, Loren E.

In: Journal of Cutaneous Pathology, Vol. 37, No. 7, 01.07.2010, p. 777-786.

Research output: Contribution to journalArticle

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