Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp

M. Levi-Strauss, M. Tosi, M. Steinmetz, J. Klein, T. Meo

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Mouse liver cDNA clones related to the C4 and C4-Slp isoforms of the fourth component of complement differ by few nucleotide changes within a region of substantial divergence from human C4. It is suggested that the mouse C4 gene duplication is an evolutionary recent event with respect to the time of mammalian radiation. This conclusion is reinforced by the presence of a single C4 gene in the Syrian hamster. Most H-2 haplotypes, including those characterized by an undetectable C4-Slp protein, possess two C4 gene copies which, in contrast to the neighboring factor B, show a marked restriction site polymorphism. The genetic variation of this regions is emphasized by the presence in the mouse of a rare 'polymorphism' for C4 gene number. Multiple C4-related gene copies characterize those exceptional wild-derived H-2 haplotypes, H-2(w7), H-2(w16), and H-2(w19), that determine the expression of the C4-Slp protein in female animals.

Original languageEnglish (US)
Pages (from-to)1746-1750
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume82
Issue number6
DOIs
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp'. Together they form a unique fingerprint.

  • Cite this