Multiple implantation after oocyte donation: A frequent but inefficient event

Richard Legro, I. L. Wong, R. J. Paulson, R. A. Lobo, M. V. Sauer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To evaluate the natural history of multiple implantation in a donor oocyte program. Design: Retrospective review of clinical pregnancies resulting from donor oocytes with analysis of serial vaginal ultrasound examinations beginning 21 days after embryo transfer. Setting: University of Southern California IVF program (USC-IVF). Main Outcome Measures: Number of implantation sites lost during gestation, furthest development of the gestation, and clinical symptoms of those experiencing loss. Results: Sixty- two of 101 patients (61%) who became pregnant had multiple implantations, 41 (41%) with two sacs, 12 (12%) with three sacs, 6 (6%) with four sacs, and 3 (3%) with five sacs. Overall 28% of implantations sites were lost spontaneously. Rates of loss were similar for multiple implantations. The majority (62%) of these nonviable sacs did not develop beyond a gestational sac. All patients with three or more implantation sites had ongoing pregnancies through the first trimester. The probability of pregnancy loss after visualization of fetal heart motion was 5.7%. Few patients who underwent a natural self reduction of sacs were symptomatic. Conclusions: There is a significant self-reduction in multiple implantation sites in a donor oocyte program. This may obviate the need for a selective reduction procedure. Patients should be followed for up to 10 weeks after ET before committing to a selective reductive procedure.

Original languageEnglish (US)
Pages (from-to)849-853
Number of pages5
JournalFertility and sterility
Volume63
Issue number4
StatePublished - Jan 1 1995

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Oocyte Donation
Oocytes
Pregnancy
Tissue Donors
Gestational Sac
Fetal Heart
Gynecological Examination
Embryo Transfer
First Pregnancy Trimester
Natural History
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Legro, R., Wong, I. L., Paulson, R. J., Lobo, R. A., & Sauer, M. V. (1995). Multiple implantation after oocyte donation: A frequent but inefficient event. Fertility and sterility, 63(4), 849-853.
Legro, Richard ; Wong, I. L. ; Paulson, R. J. ; Lobo, R. A. ; Sauer, M. V. / Multiple implantation after oocyte donation : A frequent but inefficient event. In: Fertility and sterility. 1995 ; Vol. 63, No. 4. pp. 849-853.
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Legro, R, Wong, IL, Paulson, RJ, Lobo, RA & Sauer, MV 1995, 'Multiple implantation after oocyte donation: A frequent but inefficient event', Fertility and sterility, vol. 63, no. 4, pp. 849-853.

Multiple implantation after oocyte donation : A frequent but inefficient event. / Legro, Richard; Wong, I. L.; Paulson, R. J.; Lobo, R. A.; Sauer, M. V.

In: Fertility and sterility, Vol. 63, No. 4, 01.01.1995, p. 849-853.

Research output: Contribution to journalArticle

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