Multiple transcript initiation as a mechanism for regulating gene expression

Robert E. Farrell, Jr., Carole L. Bassett

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Transcription is the intermediary process that copies a DNA-encoded gene into a form which is either functional in its own right (stable RNAs, such as ribosomal or transfer RNAs) or can be decoded by the translational machinery into a functional protein. Transcripts destined for translation are called messenger RNAs (mRNAs), since they act as go-betweens from DNA to protein. Although RNAs are transcribed as single-stranded molecules, most can assume complicated secondary and tertiary structures that are critical for proper functioning. As a result, each mRNA contains not only the sequence information required to synthesize a protein, but also structural components that can regulate mRNA localization, stability, and translation efficiency. Thus the initiation of transcription occupies a preeminent place in the regulation of gene expression.

Original languageEnglish (US)
Title of host publicationRegulation of Gene Expression in Plants
Subtitle of host publicationThe Role of Transcript Structure and Processing
PublisherSpringer US
Pages39-66
Number of pages28
Volume9780387356402
ISBN (Electronic)9780387356402
ISBN (Print)0387354492, 9780387354491
DOIs
StatePublished - Jan 1 2007

Fingerprint

messenger RNA
Gene expression
Transcription
Gene Expression
gene expression
Messenger RNA
translation (genetics)
transcription (genetics)
RNA
transfer RNA
Proteins
Ribosomal RNA
proteins
DNA
RNA Stability
gene expression regulation
Gene Expression Regulation
Transfer RNA
Machinery
Genes

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Farrell, Jr., R. E., & Bassett, C. L. (2007). Multiple transcript initiation as a mechanism for regulating gene expression. In Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing (Vol. 9780387356402, pp. 39-66). Springer US. https://doi.org/10.1007/978-0-387-35640-2_2
Farrell, Jr., Robert E. ; Bassett, Carole L. / Multiple transcript initiation as a mechanism for regulating gene expression. Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing. Vol. 9780387356402 Springer US, 2007. pp. 39-66
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Farrell, Jr., RE & Bassett, CL 2007, Multiple transcript initiation as a mechanism for regulating gene expression. in Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing. vol. 9780387356402, Springer US, pp. 39-66. https://doi.org/10.1007/978-0-387-35640-2_2

Multiple transcript initiation as a mechanism for regulating gene expression. / Farrell, Jr., Robert E.; Bassett, Carole L.

Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing. Vol. 9780387356402 Springer US, 2007. p. 39-66.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - Transcription is the intermediary process that copies a DNA-encoded gene into a form which is either functional in its own right (stable RNAs, such as ribosomal or transfer RNAs) or can be decoded by the translational machinery into a functional protein. Transcripts destined for translation are called messenger RNAs (mRNAs), since they act as go-betweens from DNA to protein. Although RNAs are transcribed as single-stranded molecules, most can assume complicated secondary and tertiary structures that are critical for proper functioning. As a result, each mRNA contains not only the sequence information required to synthesize a protein, but also structural components that can regulate mRNA localization, stability, and translation efficiency. Thus the initiation of transcription occupies a preeminent place in the regulation of gene expression.

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Farrell, Jr. RE, Bassett CL. Multiple transcript initiation as a mechanism for regulating gene expression. In Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing. Vol. 9780387356402. Springer US. 2007. p. 39-66 https://doi.org/10.1007/978-0-387-35640-2_2