Multiplicity of BMP signaling in skeletal development

Xiangwei Wu, Weibin Shi, Xu Cao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

77 Scopus citations


Skeletal development and homeostasis are complex processes involving systemic regulatory factors and local factors present in the bone microenvironment. Among these factors, bone morphogenetic proteins (BMPs) represent the major potent bone morphogens, which coordinate with other factors to exert their multiple functions by regulating cell condensation, as well as inducing chondrogenesis and osteogenesis. This article reviews the current status of BMP signaling in skeletal development, with focus on regulation at the level of the receptors. Crosstalk of the BMP pathway with other major signaling pathways is also summarized.

Original languageEnglish (US)
Title of host publicationSkeletal Biology and Medicine, Part A
Subtitle of host publicationAspects of Bone Morphogenesis and Remodeling
PublisherBlackwell Publishing Inc.
Number of pages21
ISBN (Print)9781573316842
StatePublished - Jan 1 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Wu, X., Shi, W., & Cao, X. (2007). Multiplicity of BMP signaling in skeletal development. In Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling (pp. 29-49). (Annals of the New York Academy of Sciences; Vol. 1116). Blackwell Publishing Inc..