Multiplicity of hepatic cytochrome P-450 in intact microsomes: Effect of 3-methylcholanthrene induction

Richard Mailman, W. Edmundson, K. Muse, Ernest Hodgson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalGeneral Pharmacology
Volume8
Issue number4
DOIs
StatePublished - 1977

All Science Journal Classification (ASJC) codes

  • Pharmacology

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