Abstract
1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-284 |
| Number of pages | 4 |
| Journal | General Pharmacology |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1977 |
All Science Journal Classification (ASJC) codes
- Pharmacology
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Cite this
Mailman, R., Edmundson, W., Muse, K., & Hodgson, E. (1977). Multiplicity of hepatic cytochrome P-450 in intact microsomes: Effect of 3-methylcholanthrene induction. General Pharmacology, 8(4), 281-284. https://doi.org/10.1016/0306-3623(77)90027-1