Abstract
1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-284 |
| Number of pages | 4 |
| Journal | General Pharmacology |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1977 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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}
Multiplicity of hepatic cytochrome P-450 in intact microsomes : Effect of 3-methylcholanthrene induction. / Mailman, Richard; Edmundson, W.; Muse, K.; Hodgson, Ernest.
In: General Pharmacology, Vol. 8, No. 4, 01.01.1977, p. 281-284.Research output: Contribution to journal › Article
TY - JOUR
T1 - Multiplicity of hepatic cytochrome P-450 in intact microsomes
T2 - Effect of 3-methylcholanthrene induction
AU - Mailman, Richard
AU - Edmundson, W.
AU - Muse, K.
AU - Hodgson, Ernest
PY - 1977/1/1
Y1 - 1977/1/1
N2 - 1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.
AB - 1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.
UR - http://www.scopus.com/inward/record.url?scp=0018114298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018114298&partnerID=8YFLogxK
U2 - 10.1016/0306-3623(77)90027-1
DO - 10.1016/0306-3623(77)90027-1
M3 - Article
C2 - 590736
AN - SCOPUS:0018114298
VL - 8
SP - 281
EP - 284
JO - Vascular Pharmacology
JF - Vascular Pharmacology
SN - 1537-1891
IS - 4
ER -