Multiplicity of hepatic cytochrome P-450 in intact microsomes: Effect of phenobarbital induction

Richard Mailman, G. T. Barthalmus, K. Muse, Ernest Hodgson

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Abstract

1. 1. Induction of hepatic microsomal cytochrome P-450 by phenobarbital causes distinct qualitative changes in the total cytochrome P-450, including a significant increase in the type I binding per unit of cytochrome. 2. 2. In mice, two distinct populations of cytochrome P-450 can be separated, each characteristic of microsomes of different density. 3. 3. Phenobarbital induction also causes changes in the density distribution of microsomal subfractions.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalGeneral Pharmacology
Volume8
Issue number4
DOIs
StatePublished - 1977

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All Science Journal Classification (ASJC) codes

  • Pharmacology

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