Multiplicity of hepatic cytochrome P-450 in intact microsomes: Effect of phenobarbital induction

Richard Mailman, G. T. Barthalmus, K. Muse, Ernest Hodgson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1. 1. Induction of hepatic microsomal cytochrome P-450 by phenobarbital causes distinct qualitative changes in the total cytochrome P-450, including a significant increase in the type I binding per unit of cytochrome. 2. 2. In mice, two distinct populations of cytochrome P-450 can be separated, each characteristic of microsomes of different density. 3. 3. Phenobarbital induction also causes changes in the density distribution of microsomal subfractions.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalGeneral Pharmacology
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1977

Fingerprint

Phenobarbital
Microsomes
Cytochrome P-450 Enzyme System
Liver
Cytochromes
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Mailman, Richard ; Barthalmus, G. T. ; Muse, K. ; Hodgson, Ernest. / Multiplicity of hepatic cytochrome P-450 in intact microsomes : Effect of phenobarbital induction. In: General Pharmacology. 1977 ; Vol. 8, No. 4. pp. 275-279.
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Multiplicity of hepatic cytochrome P-450 in intact microsomes : Effect of phenobarbital induction. / Mailman, Richard; Barthalmus, G. T.; Muse, K.; Hodgson, Ernest.

In: General Pharmacology, Vol. 8, No. 4, 01.01.1977, p. 275-279.

Research output: Contribution to journalArticle

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