Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Non-linearity in Tendon Tissue Mechanics

Brittany L. Banik, Gregory Lewis, Justin Lee Brown

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Abstract: Regenerative medicine plays a critical role in the future of medicine. However, challenges remain to balance stem cells, biomaterial scaffolds, and biochemical factors to create successful and effective scaffold designs. This project analyzes scaffold architecture with respect to mechanical capability and preliminary mesenchymal stem cell response for tendon regeneration. An electrospun fiber scaffold with tailorable properties based on a “Chinese-fingertrap” design is presented. The unique criss-crossed fiber structures demonstrate non-linear mechanical response similar to that observed in native tendon. Mechanical testing revealed that optimizing the fiber orientation resulted in the characteristic “S”-shaped curve, demonstrating a toe region and linear elastic region. This project has promising research potential across various disciplines: vascular engineering, nerve regeneration, and ligament and tendon tissue engineering. Lay Summary: A novel scaffold created from biodegradable fibers and incorporating unique criss-cross fiber geometry was synthesized. The scaffold recapitulated the complex non-linearity in mechanics of tendon and ligament tissues. Furthermore, the scaffold supported the growth of mesenchymal stem cells, and preliminary data suggests that the scaffold geometry encourages the differentiation of mesenchymal stem cells towards tendon.

Original languageEnglish (US)
JournalRegenerative Engineering and Translational Medicine
Volume2
Issue number1
DOIs
StatePublished - Mar 1 2016

Fingerprint

Tendons
Mechanics
Scaffolds
Tissue
Mesenchymal Stromal Cells
Stem cells
Ligaments
Fibers
Nerve Regeneration
Regenerative Medicine
Toes
Biocompatible Materials
Tissue Engineering
Blood Vessels
Regeneration
Geometry
Mechanical testing
Stem Cells
Scaffolds (biology)
Fiber reinforced materials

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cell Biology

Cite this

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title = "Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Non-linearity in Tendon Tissue Mechanics",
abstract = "Abstract: Regenerative medicine plays a critical role in the future of medicine. However, challenges remain to balance stem cells, biomaterial scaffolds, and biochemical factors to create successful and effective scaffold designs. This project analyzes scaffold architecture with respect to mechanical capability and preliminary mesenchymal stem cell response for tendon regeneration. An electrospun fiber scaffold with tailorable properties based on a “Chinese-fingertrap” design is presented. The unique criss-crossed fiber structures demonstrate non-linear mechanical response similar to that observed in native tendon. Mechanical testing revealed that optimizing the fiber orientation resulted in the characteristic “S”-shaped curve, demonstrating a toe region and linear elastic region. This project has promising research potential across various disciplines: vascular engineering, nerve regeneration, and ligament and tendon tissue engineering. Lay Summary: A novel scaffold created from biodegradable fibers and incorporating unique criss-cross fiber geometry was synthesized. The scaffold recapitulated the complex non-linearity in mechanics of tendon and ligament tissues. Furthermore, the scaffold supported the growth of mesenchymal stem cells, and preliminary data suggests that the scaffold geometry encourages the differentiation of mesenchymal stem cells towards tendon.",
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