Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America

James R. Nethercott, D. Linn Holness, Robert M. Adams, Donald V. Belsito, Vincent A. DeLeo, Edward A. Emmett, Joseph F. Fowler, Alexander M. Fisher, Walter G. Larsen, Howard I. Maibach, James Marks, Robert L. Reitschel, Lawrence Rosenthal, William Schorr, Francis J. Storrs, James S. Taylor

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Standardized patch tests were performed on 3,974 patients between August 1, 1985 and July 31, 1989. Significant determinants of positive responses based on previously reported bivariate analysis of response were entered into a logistic regression model; the contribution of each factor to response to each of 27 test substances with which the patients were tested was evaluated. For 14 test substances, age increased the odds of response; nickel was striking in that increasing age decreased the odds of a positive response. Specific contactants were found to be associated with gender and topographical location of the eczematous dermatitis leading to the application of the patch tests. Atopic dermatitis was associated with a lower odds of response to P-phenylenediamine, but in no instance was associated with increased odds of a positive response.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalAmerican Journal of Contact Dermatitis
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1994

Fingerprint

Patch Tests
North America
Multivariate Analysis
Logistic Models
Phenylenediamines
Eczema
Atopic Dermatitis
Nickel

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Nethercott, James R. ; Linn Holness, D. ; Adams, Robert M. ; Belsito, Donald V. ; DeLeo, Vincent A. ; Emmett, Edward A. ; Fowler, Joseph F. ; Fisher, Alexander M. ; Larsen, Walter G. ; Maibach, Howard I. ; Marks, James ; Reitschel, Robert L. ; Rosenthal, Lawrence ; Schorr, William ; Storrs, Francis J. ; Taylor, James S. / Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America. In: American Journal of Contact Dermatitis. 1994 ; Vol. 5, No. 1. pp. 13-18.
@article{c40342ee6f4847b2b3048c8ac0416ae3,
title = "Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America",
abstract = "Standardized patch tests were performed on 3,974 patients between August 1, 1985 and July 31, 1989. Significant determinants of positive responses based on previously reported bivariate analysis of response were entered into a logistic regression model; the contribution of each factor to response to each of 27 test substances with which the patients were tested was evaluated. For 14 test substances, age increased the odds of response; nickel was striking in that increasing age decreased the odds of a positive response. Specific contactants were found to be associated with gender and topographical location of the eczematous dermatitis leading to the application of the patch tests. Atopic dermatitis was associated with a lower odds of response to P-phenylenediamine, but in no instance was associated with increased odds of a positive response.",
author = "Nethercott, {James R.} and {Linn Holness}, D. and Adams, {Robert M.} and Belsito, {Donald V.} and DeLeo, {Vincent A.} and Emmett, {Edward A.} and Fowler, {Joseph F.} and Fisher, {Alexander M.} and Larsen, {Walter G.} and Maibach, {Howard I.} and James Marks and Reitschel, {Robert L.} and Lawrence Rosenthal and William Schorr and Storrs, {Francis J.} and Taylor, {James S.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1097/01634989-199403000-00002",
language = "English (US)",
volume = "5",
pages = "13--18",
journal = "Dermatitis",
issn = "1710-3568",
publisher = "Decker Publishing",
number = "1",

}

Nethercott, JR, Linn Holness, D, Adams, RM, Belsito, DV, DeLeo, VA, Emmett, EA, Fowler, JF, Fisher, AM, Larsen, WG, Maibach, HI, Marks, J, Reitschel, RL, Rosenthal, L, Schorr, W, Storrs, FJ & Taylor, JS 1994, 'Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America', American Journal of Contact Dermatitis, vol. 5, no. 1, pp. 13-18. https://doi.org/10.1097/01634989-199403000-00002

Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America. / Nethercott, James R.; Linn Holness, D.; Adams, Robert M.; Belsito, Donald V.; DeLeo, Vincent A.; Emmett, Edward A.; Fowler, Joseph F.; Fisher, Alexander M.; Larsen, Walter G.; Maibach, Howard I.; Marks, James; Reitschel, Robert L.; Rosenthal, Lawrence; Schorr, William; Storrs, Francis J.; Taylor, James S.

In: American Journal of Contact Dermatitis, Vol. 5, No. 1, 01.01.1994, p. 13-18.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America

AU - Nethercott, James R.

AU - Linn Holness, D.

AU - Adams, Robert M.

AU - Belsito, Donald V.

AU - DeLeo, Vincent A.

AU - Emmett, Edward A.

AU - Fowler, Joseph F.

AU - Fisher, Alexander M.

AU - Larsen, Walter G.

AU - Maibach, Howard I.

AU - Marks, James

AU - Reitschel, Robert L.

AU - Rosenthal, Lawrence

AU - Schorr, William

AU - Storrs, Francis J.

AU - Taylor, James S.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Standardized patch tests were performed on 3,974 patients between August 1, 1985 and July 31, 1989. Significant determinants of positive responses based on previously reported bivariate analysis of response were entered into a logistic regression model; the contribution of each factor to response to each of 27 test substances with which the patients were tested was evaluated. For 14 test substances, age increased the odds of response; nickel was striking in that increasing age decreased the odds of a positive response. Specific contactants were found to be associated with gender and topographical location of the eczematous dermatitis leading to the application of the patch tests. Atopic dermatitis was associated with a lower odds of response to P-phenylenediamine, but in no instance was associated with increased odds of a positive response.

AB - Standardized patch tests were performed on 3,974 patients between August 1, 1985 and July 31, 1989. Significant determinants of positive responses based on previously reported bivariate analysis of response were entered into a logistic regression model; the contribution of each factor to response to each of 27 test substances with which the patients were tested was evaluated. For 14 test substances, age increased the odds of response; nickel was striking in that increasing age decreased the odds of a positive response. Specific contactants were found to be associated with gender and topographical location of the eczematous dermatitis leading to the application of the patch tests. Atopic dermatitis was associated with a lower odds of response to P-phenylenediamine, but in no instance was associated with increased odds of a positive response.

UR - http://www.scopus.com/inward/record.url?scp=38149145607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149145607&partnerID=8YFLogxK

U2 - 10.1097/01634989-199403000-00002

DO - 10.1097/01634989-199403000-00002

M3 - Article

AN - SCOPUS:38149145607

VL - 5

SP - 13

EP - 18

JO - Dermatitis

JF - Dermatitis

SN - 1710-3568

IS - 1

ER -