Murine antigen H-2.7: Its genetics, tissue expression, and strain distribution

Chun Ming Huang, Jan Klein

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Abstract

Reinvestigation of alloantisera containing antibodies to murine antigen H-2.7 revealed that the crucial recombinant, A.TFR1 (H-2an1), which was reported to separate the H-2G locus from the Ss-Slp loci, has a k-like instead of f-like H-2.7 antigen. Therefore, the crossover position in H-2an1 and the position of the G locus in the H-2 map are now uncertain. By using the hemagglutination-serum inhibition test, anti-H-2.7 reactive substance was found to be present in normal mouse serum in a strain-specific manner. Tissue distribution study by absorption analysis indicated that H-2.7 antigen is present, in addition to RBCs, on spleen and lymph node cells, but is absent on thymus cells. Thirty B10.W congenic lines were analysed for the presence of the H-2.7 antigen. Two lines (B 10.CHA2 and B 10.KPA44) were found to be H-2.7 positive by both direct hemagglutination and absorption tests.

Original languageEnglish (US)
Pages (from-to)233-243
Number of pages11
JournalImmunogenetics
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1979

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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