Muscle acidosis during static exercise is associated with calf vasoconstriction

Lawrence Sinoway, S. Prophet, I. Gorman, Timothy Mosher, J. Shenberger, M. Dolecki, R. Briggs, Robert Zelis

Research output: Contribution to journalArticle

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Abstract

In this study we measured (n=6) the phosphocreatine-to-inorganic phosphate ratio (PCr/P(i)), P(i), and pH with 31P-nuclear magnetic resonance (31P-NMR) in the human forearm during static work at 30% of maximal voluntary contraction (MVC) for 2 min followed immediately by 3 min of circulatory arrest (forearm arterial occlusion). Static exercise, with its central volitional and skeletal muscle metabolic and mechanical afferent components, caused a rise in heart rate (HR, 32%), blood pressure (BP, 29%), and calf vascular resistance (calf R, 30%). During forearm occlusion after static exercise, HR returned to base line, the increase in BP was attenuated by 30%, and calf R remained elevated and unchanged. The percent change in calf R was correlated with forearm cellular pH (R=0.56, P<0.001) but only weakly associated with PCr/P(i) (R=0.33, P<0.042). 30% MVC for 1 min followed by arterial occlusion (3 min) reduced PCr/P(i) by 65% and pH by 0.16 U (P<0.05). Calf R was unchanged. Circulatory arrest alone (20 min) caused no change in either pH or calf R but large changes in PCr/P(i) (50% reduction). We conclude that 1) there is an association between forearm cellular acidosis and calf vasoconstriction during static forearm exercise and 2) large changes in PCr/P(i) without concomitant changes in pH are not associated with changes in calf R.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalJournal of Applied Physiology
Volume66
Issue number1
StatePublished - Jan 1 1989

Fingerprint

Acidosis
Vasoconstriction
Forearm
Muscles
Phosphocreatine
Vascular Resistance
Skeletal Muscle
Magnetic Resonance Spectroscopy
Heart Rate
Phosphates
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Sinoway, Lawrence ; Prophet, S. ; Gorman, I. ; Mosher, Timothy ; Shenberger, J. ; Dolecki, M. ; Briggs, R. ; Zelis, Robert. / Muscle acidosis during static exercise is associated with calf vasoconstriction. In: Journal of Applied Physiology. 1989 ; Vol. 66, No. 1. pp. 429-436.
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abstract = "In this study we measured (n=6) the phosphocreatine-to-inorganic phosphate ratio (PCr/P(i)), P(i), and pH with 31P-nuclear magnetic resonance (31P-NMR) in the human forearm during static work at 30{\%} of maximal voluntary contraction (MVC) for 2 min followed immediately by 3 min of circulatory arrest (forearm arterial occlusion). Static exercise, with its central volitional and skeletal muscle metabolic and mechanical afferent components, caused a rise in heart rate (HR, 32{\%}), blood pressure (BP, 29{\%}), and calf vascular resistance (calf R, 30{\%}). During forearm occlusion after static exercise, HR returned to base line, the increase in BP was attenuated by 30{\%}, and calf R remained elevated and unchanged. The percent change in calf R was correlated with forearm cellular pH (R=0.56, P<0.001) but only weakly associated with PCr/P(i) (R=0.33, P<0.042). 30{\%} MVC for 1 min followed by arterial occlusion (3 min) reduced PCr/P(i) by 65{\%} and pH by 0.16 U (P<0.05). Calf R was unchanged. Circulatory arrest alone (20 min) caused no change in either pH or calf R but large changes in PCr/P(i) (50{\%} reduction). We conclude that 1) there is an association between forearm cellular acidosis and calf vasoconstriction during static forearm exercise and 2) large changes in PCr/P(i) without concomitant changes in pH are not associated with changes in calf R.",
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Sinoway, L, Prophet, S, Gorman, I, Mosher, T, Shenberger, J, Dolecki, M, Briggs, R & Zelis, R 1989, 'Muscle acidosis during static exercise is associated with calf vasoconstriction', Journal of Applied Physiology, vol. 66, no. 1, pp. 429-436.

Muscle acidosis during static exercise is associated with calf vasoconstriction. / Sinoway, Lawrence; Prophet, S.; Gorman, I.; Mosher, Timothy; Shenberger, J.; Dolecki, M.; Briggs, R.; Zelis, Robert.

In: Journal of Applied Physiology, Vol. 66, No. 1, 01.01.1989, p. 429-436.

Research output: Contribution to journalArticle

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AU - Sinoway, Lawrence

AU - Prophet, S.

AU - Gorman, I.

AU - Mosher, Timothy

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AU - Dolecki, M.

AU - Briggs, R.

AU - Zelis, Robert

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N2 - In this study we measured (n=6) the phosphocreatine-to-inorganic phosphate ratio (PCr/P(i)), P(i), and pH with 31P-nuclear magnetic resonance (31P-NMR) in the human forearm during static work at 30% of maximal voluntary contraction (MVC) for 2 min followed immediately by 3 min of circulatory arrest (forearm arterial occlusion). Static exercise, with its central volitional and skeletal muscle metabolic and mechanical afferent components, caused a rise in heart rate (HR, 32%), blood pressure (BP, 29%), and calf vascular resistance (calf R, 30%). During forearm occlusion after static exercise, HR returned to base line, the increase in BP was attenuated by 30%, and calf R remained elevated and unchanged. The percent change in calf R was correlated with forearm cellular pH (R=0.56, P<0.001) but only weakly associated with PCr/P(i) (R=0.33, P<0.042). 30% MVC for 1 min followed by arterial occlusion (3 min) reduced PCr/P(i) by 65% and pH by 0.16 U (P<0.05). Calf R was unchanged. Circulatory arrest alone (20 min) caused no change in either pH or calf R but large changes in PCr/P(i) (50% reduction). We conclude that 1) there is an association between forearm cellular acidosis and calf vasoconstriction during static forearm exercise and 2) large changes in PCr/P(i) without concomitant changes in pH are not associated with changes in calf R.

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