Muscle sympathetic outflow during horizontal linear acceleration in humans

Jian Cui, Satoshi Iwase, Tadaaki Mano, Naomi Katayama, Shigeo Mori

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To elucidate the effects of linear acceleration on muscle sympathetic nerve activity (MSNA) in humans, 16 healthy men were tested in a linear accelerator. Measurements of MSNA, electrocardiogram, blood pressure, and thoracic impedance were undertaken during linear acceleration. Sinusoidal linear acceleration with peak values at ±0.10, ±0.15, and ±0.20 G was applied in anteroposterior (±Gx, n = 10) or lateral (±Gy, n = 6) directions. The total activity and burst rate of MSNA decreased significantly during forward, backward, left, or right linear accelerations. The total activity of MSNA decreased to 50.5 ± 6.9, 52.5 ± 4.4, 71.2 ± 9.6, and 67.6 ± 8.2% from the baselines (100%) during linear accelerations with peak values at ±0.20 G in the four directions, respectively. These results suggest that dynamic stimulation of otolith organs in horizontal directions in humans might inhibit MSNA directly in order to quickly redistribute blood to muscles during postural reflexes induced by passive movement, which supports the concept that the vestibular system contributes to sympathetic regulation in humans.

Original languageEnglish (US)
Pages (from-to)R625-R634
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume281
Issue number2 50-2
StatePublished - Aug 29 2001

Fingerprint

Muscles
Otolithic Membrane
Particle Accelerators
Electric Impedance
Human Activities
Reflex
Electrocardiography
Thorax
Blood Pressure
Direction compound

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Cui, Jian ; Iwase, Satoshi ; Mano, Tadaaki ; Katayama, Naomi ; Mori, Shigeo. / Muscle sympathetic outflow during horizontal linear acceleration in humans. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2001 ; Vol. 281, No. 2 50-2. pp. R625-R634.
@article{4c668bb2399e4c6fbf8415db7e5b48ef,
title = "Muscle sympathetic outflow during horizontal linear acceleration in humans",
abstract = "To elucidate the effects of linear acceleration on muscle sympathetic nerve activity (MSNA) in humans, 16 healthy men were tested in a linear accelerator. Measurements of MSNA, electrocardiogram, blood pressure, and thoracic impedance were undertaken during linear acceleration. Sinusoidal linear acceleration with peak values at ±0.10, ±0.15, and ±0.20 G was applied in anteroposterior (±Gx, n = 10) or lateral (±Gy, n = 6) directions. The total activity and burst rate of MSNA decreased significantly during forward, backward, left, or right linear accelerations. The total activity of MSNA decreased to 50.5 ± 6.9, 52.5 ± 4.4, 71.2 ± 9.6, and 67.6 ± 8.2{\%} from the baselines (100{\%}) during linear accelerations with peak values at ±0.20 G in the four directions, respectively. These results suggest that dynamic stimulation of otolith organs in horizontal directions in humans might inhibit MSNA directly in order to quickly redistribute blood to muscles during postural reflexes induced by passive movement, which supports the concept that the vestibular system contributes to sympathetic regulation in humans.",
author = "Jian Cui and Satoshi Iwase and Tadaaki Mano and Naomi Katayama and Shigeo Mori",
year = "2001",
month = "8",
day = "29",
language = "English (US)",
volume = "281",
pages = "R625--R634",
journal = "American Journal of Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "2 50-2",

}

Muscle sympathetic outflow during horizontal linear acceleration in humans. / Cui, Jian; Iwase, Satoshi; Mano, Tadaaki; Katayama, Naomi; Mori, Shigeo.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 281, No. 2 50-2, 29.08.2001, p. R625-R634.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Muscle sympathetic outflow during horizontal linear acceleration in humans

AU - Cui, Jian

AU - Iwase, Satoshi

AU - Mano, Tadaaki

AU - Katayama, Naomi

AU - Mori, Shigeo

PY - 2001/8/29

Y1 - 2001/8/29

N2 - To elucidate the effects of linear acceleration on muscle sympathetic nerve activity (MSNA) in humans, 16 healthy men were tested in a linear accelerator. Measurements of MSNA, electrocardiogram, blood pressure, and thoracic impedance were undertaken during linear acceleration. Sinusoidal linear acceleration with peak values at ±0.10, ±0.15, and ±0.20 G was applied in anteroposterior (±Gx, n = 10) or lateral (±Gy, n = 6) directions. The total activity and burst rate of MSNA decreased significantly during forward, backward, left, or right linear accelerations. The total activity of MSNA decreased to 50.5 ± 6.9, 52.5 ± 4.4, 71.2 ± 9.6, and 67.6 ± 8.2% from the baselines (100%) during linear accelerations with peak values at ±0.20 G in the four directions, respectively. These results suggest that dynamic stimulation of otolith organs in horizontal directions in humans might inhibit MSNA directly in order to quickly redistribute blood to muscles during postural reflexes induced by passive movement, which supports the concept that the vestibular system contributes to sympathetic regulation in humans.

AB - To elucidate the effects of linear acceleration on muscle sympathetic nerve activity (MSNA) in humans, 16 healthy men were tested in a linear accelerator. Measurements of MSNA, electrocardiogram, blood pressure, and thoracic impedance were undertaken during linear acceleration. Sinusoidal linear acceleration with peak values at ±0.10, ±0.15, and ±0.20 G was applied in anteroposterior (±Gx, n = 10) or lateral (±Gy, n = 6) directions. The total activity and burst rate of MSNA decreased significantly during forward, backward, left, or right linear accelerations. The total activity of MSNA decreased to 50.5 ± 6.9, 52.5 ± 4.4, 71.2 ± 9.6, and 67.6 ± 8.2% from the baselines (100%) during linear accelerations with peak values at ±0.20 G in the four directions, respectively. These results suggest that dynamic stimulation of otolith organs in horizontal directions in humans might inhibit MSNA directly in order to quickly redistribute blood to muscles during postural reflexes induced by passive movement, which supports the concept that the vestibular system contributes to sympathetic regulation in humans.

UR - http://www.scopus.com/inward/record.url?scp=0034892374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034892374&partnerID=8YFLogxK

M3 - Article

C2 - 11448868

AN - SCOPUS:0034892374

VL - 281

SP - R625-R634

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 2 50-2

ER -