Musculoskeletal complaints and serum autoantibodies associated with chronic hepatitis C and nonalcoholic fatty liver disease

Sharon E. Banks, Thomas R. Riley, Stanley J. Naides

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We sought to compare the musculoskeletal symptoms and immune markers found in chronic hepatitis C (HCV) and nonalcoholic fatty liver disease (NAFLD). Patients with HCV or NAFLD answered a questionnaire and donated serum for autoantibody testing. Univariate analysis between the HCV and NAFLD groups revealed joint pain in 67% of the HCV group and 65% of the NAFLD group. Those with joint pain reported inflammatory characteristics that were similar between the groups. The presence of a positive rheumatoid factor and cryoglobulins was higher in the HCV group, however both groups had a similar prevalence of a low positive antinuclear antibody (ANA). We conclude that the NAFLD group reported a higher amount of joint pain and inflammatory joint symptoms than anticipated. We were unable to determine a variable that predicted the presence of joint pain. Therefore, more investigation is needed to determine whether these findings are due to liver disease alone.

Original languageEnglish (US)
Pages (from-to)1177-1182
Number of pages6
JournalDigestive Diseases and Sciences
Volume52
Issue number5
DOIs
StatePublished - May 1 2007

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Chronic Hepatitis C
Autoantibodies
Arthralgia
Serum
Cryoglobulins
Rheumatoid Factor
Antinuclear Antibodies
Liver Diseases
Joints
Biomarkers
Non-alcoholic Fatty Liver Disease

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

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