Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis

Jason D. Graci, Nina F. Gnädig, Jessica E. Galarraga, Christian Castro, Marco Vignuzzi, Craig E. Cameron

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the viral population. We suggest that mutational robustness may be a useful measure of the sensitivity of a virus to lethal mutagenesis.

Original languageEnglish (US)
Pages (from-to)2869-2873
Number of pages5
JournalJournal of virology
Volume86
Issue number5
DOIs
StatePublished - Mar 2012

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Graci, J. D., Gnädig, N. F., Galarraga, J. E., Castro, C., Vignuzzi, M., & Cameron, C. E. (2012). Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. Journal of virology, 86(5), 2869-2873. https://doi.org/10.1128/JVI.05712-11