Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis

Jason D. Graci, Nina F. Gnädig, Jessica E. Galarraga, Christian Castro, Marco Vignuzzi, Craig E. Cameron

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the viral population. We suggest that mutational robustness may be a useful measure of the sensitivity of a virus to lethal mutagenesis.

Original languageEnglish (US)
Pages (from-to)2869-2873
Number of pages5
JournalJournal of virology
Volume86
Issue number5
DOIs
StatePublished - Mar 1 2012

Fingerprint

Enterovirus
RNA Viruses
lethal genes
mutagenesis
Mutagenesis
Poliovirus
Mutagens
Population Genetics
Population Dynamics
Mutation Rate
Population Density
Enterovirus C
Viruses
population genetics
reproductive performance
Population
mutation
viruses
RNA viruses

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Graci, J. D., Gnädig, N. F., Galarraga, J. E., Castro, C., Vignuzzi, M., & Cameron, C. E. (2012). Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. Journal of virology, 86(5), 2869-2873. https://doi.org/10.1128/JVI.05712-11
Graci, Jason D. ; Gnädig, Nina F. ; Galarraga, Jessica E. ; Castro, Christian ; Vignuzzi, Marco ; Cameron, Craig E. / Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. In: Journal of virology. 2012 ; Vol. 86, No. 5. pp. 2869-2873.
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Graci, JD, Gnädig, NF, Galarraga, JE, Castro, C, Vignuzzi, M & Cameron, CE 2012, 'Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis', Journal of virology, vol. 86, no. 5, pp. 2869-2873. https://doi.org/10.1128/JVI.05712-11

Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. / Graci, Jason D.; Gnädig, Nina F.; Galarraga, Jessica E.; Castro, Christian; Vignuzzi, Marco; Cameron, Craig E.

In: Journal of virology, Vol. 86, No. 5, 01.03.2012, p. 2869-2873.

Research output: Contribution to journalArticle

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Graci JD, Gnädig NF, Galarraga JE, Castro C, Vignuzzi M, Cameron CE. Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. Journal of virology. 2012 Mar 1;86(5):2869-2873. https://doi.org/10.1128/JVI.05712-11