Abstract
As a major factor in Plasmodium falciparum malaria pathogenesis, the var gene family has been the focus of extensive research, which has contributed to our current understanding of Plasmodium antigenic variation. In recent years, sophisticated molecular tools have enabled the generation of interesting data regarding the regulation of mutually exclusive var expression. Although their results are still inconclusive, these studies have demonstrated the existence of multiple layers of control over gene activation, silencing, memory and 'counting'. This review attempts to summarize recent findings and dissect the different layers of var regulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 455-461 |
| Number of pages | 7 |
| Journal | Trends in Parasitology |
| Volume | 24 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2008 |
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All Science Journal Classification (ASJC) codes
- Infectious Diseases
- Parasitology
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Mutually exclusive var gene expression in the malaria parasite : multiple layers of regulation. / Chookajorn, Thanat; Ponsuwanna, Patrath; Cui, Liwang.
In: Trends in Parasitology, Vol. 24, No. 10, 01.10.2008, p. 455-461.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Mutually exclusive var gene expression in the malaria parasite
T2 - multiple layers of regulation
AU - Chookajorn, Thanat
AU - Ponsuwanna, Patrath
AU - Cui, Liwang
PY - 2008/10/1
Y1 - 2008/10/1
N2 - As a major factor in Plasmodium falciparum malaria pathogenesis, the var gene family has been the focus of extensive research, which has contributed to our current understanding of Plasmodium antigenic variation. In recent years, sophisticated molecular tools have enabled the generation of interesting data regarding the regulation of mutually exclusive var expression. Although their results are still inconclusive, these studies have demonstrated the existence of multiple layers of control over gene activation, silencing, memory and 'counting'. This review attempts to summarize recent findings and dissect the different layers of var regulation.
AB - As a major factor in Plasmodium falciparum malaria pathogenesis, the var gene family has been the focus of extensive research, which has contributed to our current understanding of Plasmodium antigenic variation. In recent years, sophisticated molecular tools have enabled the generation of interesting data regarding the regulation of mutually exclusive var expression. Although their results are still inconclusive, these studies have demonstrated the existence of multiple layers of control over gene activation, silencing, memory and 'counting'. This review attempts to summarize recent findings and dissect the different layers of var regulation.
UR - http://www.scopus.com/inward/record.url?scp=51449122039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51449122039&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2008.07.005
DO - 10.1016/j.pt.2008.07.005
M3 - Review article
C2 - 18771955
AN - SCOPUS:51449122039
VL - 24
SP - 455
EP - 461
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 10
ER -