Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation

Thanat Chookajorn, Patrath Ponsuwanna, Liwang Cui

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

As a major factor in Plasmodium falciparum malaria pathogenesis, the var gene family has been the focus of extensive research, which has contributed to our current understanding of Plasmodium antigenic variation. In recent years, sophisticated molecular tools have enabled the generation of interesting data regarding the regulation of mutually exclusive var expression. Although their results are still inconclusive, these studies have demonstrated the existence of multiple layers of control over gene activation, silencing, memory and 'counting'. This review attempts to summarize recent findings and dissect the different layers of var regulation.

Original languageEnglish (US)
Pages (from-to)455-461
Number of pages7
JournalTrends in Parasitology
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2008

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Parasitology

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