Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant: Report of clinical response to treatment with tigecycline

E. Peres, Y. Khaled, O. I. Krijanovski, S. Mineishi, J. E. Levine, D. R. Kaul, J. Riddell IV

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We present a case of progressive Mycobacterium chelonae ssp. chelonae necrotizing pneumonia after hematopoietic stem cell transplantation (HSCT) in the presence of chronic graft-versus-host disease. The patient failed to respond to standard combination therapy with multiple agents and developed resistance to most drugs over the course of treatment. Tigecycline, a new glycylcycline antimicrobial agent with in vitro activity against M. chelonae, was then used with a clinical response to treatment. To our knowledge, this is the first reported case demonstrating tigecycline to have a degree of clinical effectiveness to treat refractory pulmonary infection with M. chelonae in an HSCT recipient.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalTransplant Infectious Disease
Volume11
Issue number1
DOIs
StatePublished - Feb 2009

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Transplantation

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