Mycobacterium tuberculosis-induced cytokine and chemokine expression by human microglia and astrocytes: Effects of dexamethasone

R. Bryan Rock, Shuxian Hu, Genya Gekker, Wen S. Sheng, Barbara May, Vivek Kapur, Phillip K. Peterson

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Although corticosteroids are recommended as adjunctive therapy for tuberculous meningitis, the mechanism underlying their beneficial effect is poorly understood. In this study, human microglia and astrocytes were infected with Mycobacterium tuberculosis H37Rv, and cytokine and chemokine expression was examined with and without dexamethasone treatment. Microglia were the principal cells infected by tubercle bacilli, which elicited robust amounts of several cytokines and chemokines. Treatment with dexamethasone markedly suppressed production of these mediators. The results of this study support the concept that micreglia play an important role in neuropathogenesis of tuberculosis and that dexamethasone could operate via modulation of the production of proinflammatory cytokines and chemokines by these brain macrophages.

Original languageEnglish (US)
Pages (from-to)2054-2058
Number of pages5
JournalJournal of Infectious Diseases
Volume192
Issue number12
DOIs
StatePublished - Dec 15 2005

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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