Myelination in children with partial deletions of chromosome 18q

Jack L. Lancaster, Jannine D. Cody, Trevor Andrews, L. Jean Hardies, Daniel E. Hale, Peter T. Fox

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Abstract

BACKGROUND AND PURPOSE: We compared myelin levels in white matter (WM) in typically developing children with those of children with partial deletions of chromosome 18q (18q-). METHODS: Conventional spin-echo MR imaging at 1.9T was used to acquire T1-, T2-, and proton density-weighted images of the brain. From these images, a three-pool model was used to estimate the fraction of water in myelin, myelinated axon, and mixed water compartments (or pools) in six WM regions. A model curve was fit to the pool fractions to model the trend of myelin development by age in each region. Water-pool fractions in children with 18q- aged 5 months to 13 years were compared with those of age-matched, typically developing children. RESULTS: In children with 18q-, the model predicted later onset of myelination (P < .02), lower myelination rates (P < .001), and smaller equilibrium myelin pool fractions (P < .001). Significant differences were seen between the two groups for all three water pool fractions (P < .001). The mixed pool fraction was larger in children with 18q-. Although the myelin pool fraction was significantly smaller, the myelinated axon pool fraction was only slightly smaller, leading to a significantly smaller estimate of myelin per myelinated axon in children with 18q-(P < .001). CONCLUSION: Myelination modeling in 18q- children indicated delayed onset, a lower rate of myelination, and equilibrium myelin levels less than 50% those of age-matched, typically developing children.

Original languageEnglish (US)
Pages (from-to)447-454
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume26
Issue number3
StatePublished - Dec 1 2005

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Lancaster, J. L., Cody, J. D., Andrews, T., Hardies, L. J., Hale, D. E., & Fox, P. T. (2005). Myelination in children with partial deletions of chromosome 18q. American Journal of Neuroradiology, 26(3), 447-454.