Myocardial and Pancreatic Lesions Induced by T-2 Toxin, a Trichothecene Mycotoxin, in Swine

V. F. Pang, J. H. Adams, Val Richard Beasley, W. B. Buck, W. M. Haschek

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Myocardial and pancreatic lesions induced by sublethal doses of T-2 toxin in swine were characterized by light and electron microscopy. Toxin was given intravenously to six 17- to 18-week-old pigs. Pigs were killed 24 or 48 hours after treatment. Grossly, subendocardial hemorrhages, multifocal pinpoint white foci in myocardium, and pancreatic edema occurred in one treated pig. Histologic changes in myocardium of treated pigs consisted of multifocal edema, mononuclear cell infiltration, myofiber hyalinization, vacuolation, and contraction bands with nuclear pyknosis. Ultrastructurally, there were areas of edema, myofibrillar disorganization, dilation of sarcoplasmic reticulum, and formation of hypercontraction bands. Myocardial mineralization was seen in the pig with gross lesions. Pancreatic changes in treated pigs consisted of multifocal acinar degeneration and necrosis. Ultrastructural changes included irregular dilation of rough endoplasmic reticulum and abnormal zymogen granules. Thus, in addition to radiomimetic lesions of the gastrointestinal tract and lymphoid organs, heart and pancreas are target organs of T-2 toxin in swine.

Original languageEnglish (US)
Pages (from-to)310-319
Number of pages10
JournalVeterinary Pathology
Volume23
Issue number3
DOIs
StatePublished - Jan 1 1986

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T-2 Toxin
Trichothecenes
T-2 toxin
trichothecenes
Mycotoxins
lesions (animal)
mycotoxins
Swine
swine
edema
Edema
myocardium
Dilatation
Myocardium
sarcoplasmic reticulum
Rough Endoplasmic Reticulum
secretory granules
rough endoplasmic reticulum
Secretory Vesicles
Sarcoplasmic Reticulum

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Pang, V. F. ; Adams, J. H. ; Beasley, Val Richard ; Buck, W. B. ; Haschek, W. M. / Myocardial and Pancreatic Lesions Induced by T-2 Toxin, a Trichothecene Mycotoxin, in Swine. In: Veterinary Pathology. 1986 ; Vol. 23, No. 3. pp. 310-319.
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Myocardial and Pancreatic Lesions Induced by T-2 Toxin, a Trichothecene Mycotoxin, in Swine. / Pang, V. F.; Adams, J. H.; Beasley, Val Richard; Buck, W. B.; Haschek, W. M.

In: Veterinary Pathology, Vol. 23, No. 3, 01.01.1986, p. 310-319.

Research output: Contribution to journalArticle

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