Myocardial infarction does not affect fatty-acid profiles in rats

Gregory C. Shearer, Jinghai Chen, Yuefeng Chen, William S. Harris

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Plasma and red blood cell fatty-acid (RBC FA) composition have both been proposed as biomarkers for cardiovascular (CV) risk. Since case/control studies using samples obtained after a CV constitute a source of supporting evidence, demonstrating that FA profiles are not affected by a myocardial infarction (MI) would improve our understanding of the usefulness of such studies. The primary goal of the present study was to determine the impact of an MI on RBC and whole plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels and to do so with sufficient power to conclude that there was no effect. FA profiles were obtained from rats 24 h after an MI or a sham-MI and compared to control animals by tests for differences and equivalence. In RBCs, neither DHA nor EPA was changed and were statistically equivalent in control and MI rats, as were a majority of other FAs and FA composite indices; only shingolipid-associated fatty acids had abundances that were changed in either MI or sham-MI animals. In whole plasma 8 of 22 FAs were changed in MI or sham-MI rats, including EPA which was reduced from 2.53 (2.3, 2.8)% to 1.71 (1.4, 2)%; mean (95% CI). In conclusion, the levels of EPA, DHA, and most other FAs in RBCs are unaffected by an MI or by sham surgery, whereas the same cannot be said of plasma. This finding suggests that differences between cases and controls have prognostic implications.

Original languageEnglish (US)
Pages (from-to)411-416
Number of pages6
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume81
Issue number5-6
DOIs
StatePublished - Nov 1 2009

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Eicosapentaenoic Acid
Docosahexaenoic Acids
Rats
Fatty Acids
Myocardial Infarction
Plasmas
Animals
Biomarkers
Surgery
Blood
Cells
Composite materials
Chemical analysis
Case-Control Studies
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

Cite this

Shearer, Gregory C. ; Chen, Jinghai ; Chen, Yuefeng ; Harris, William S. / Myocardial infarction does not affect fatty-acid profiles in rats. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2009 ; Vol. 81, No. 5-6. pp. 411-416.
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Myocardial infarction does not affect fatty-acid profiles in rats. / Shearer, Gregory C.; Chen, Jinghai; Chen, Yuefeng; Harris, William S.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 81, No. 5-6, 01.11.2009, p. 411-416.

Research output: Contribution to journalArticle

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