N-methoxy-n-methylamides as effective acylating agents

Steven Nahm, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

1661 Scopus citations

Abstract

Readily preparable N-methoxy-N-methylamides couple in good yields with Grignard and organolithium reagents to produce ketones, and are reduced with hydrides to afford aldehydes.

Original languageEnglish (US)
Pages (from-to)3815-3818
Number of pages4
JournalTetrahedron Letters
Volume22
Issue number39
DOIs
StatePublished - 1981

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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