NAC1 and HMGB1 enter a partnership for manipulating autophagy

Yi Zhang, Jay W. Yang, Xingcong Ren, Jin Ming Yang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Our recent study revealed a new role of nucleus accumbens-1 (NAC1), a transcription factor belonging to the BTB/POZ gene family, in regulating autophagy. Moreover, we found that the high-mobility group box 1 (HMGB1), a chromatin-associated nuclear protein acting as an extracellular damage associated molecular pattern molecule (DAMP), is the downstream executor of NAC1 in modulating autophagy. In response to stress such as therapeutic insults, NAC1 increases the expression, cytosolic translocation and release of HMGB1; elevated level of the cytoplasmic HMGB1 leads to activation of autophagy. The NAC1-HMGB1 partnership may represent a previously unrecognized pathway that regulates autophagy in response to various stresses such as chemotherapy.

Original languageEnglish (US)
Pages (from-to)1557-1558
Number of pages2
JournalAutophagy
Volume7
Issue number12
DOIs
StatePublished - Dec 2011

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Autophagy
Nucleus Accumbens
Nuclear Proteins
Chromatin
Transcription Factors
Drug Therapy
Genes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Zhang, Y., Yang, J. W., Ren, X., & Yang, J. M. (2011). NAC1 and HMGB1 enter a partnership for manipulating autophagy. Autophagy, 7(12), 1557-1558. https://doi.org/10.4161/auto.7.12.17910
Zhang, Yi ; Yang, Jay W. ; Ren, Xingcong ; Yang, Jin Ming. / NAC1 and HMGB1 enter a partnership for manipulating autophagy. In: Autophagy. 2011 ; Vol. 7, No. 12. pp. 1557-1558.
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Zhang, Y, Yang, JW, Ren, X & Yang, JM 2011, 'NAC1 and HMGB1 enter a partnership for manipulating autophagy', Autophagy, vol. 7, no. 12, pp. 1557-1558. https://doi.org/10.4161/auto.7.12.17910

NAC1 and HMGB1 enter a partnership for manipulating autophagy. / Zhang, Yi; Yang, Jay W.; Ren, Xingcong; Yang, Jin Ming.

In: Autophagy, Vol. 7, No. 12, 12.2011, p. 1557-1558.

Research output: Contribution to journalArticle

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