Na,K-ATPase α and β subunit genes exhibit unique expression patterns during zebrafish embryogenesis

Victor Canfield, Benjamin Loppin, Bernard Thisse, Christine Thisse, John H. Postlethwait, Manzoor Ali P.K. Mohideen, S. Johannes R. Rajarao, Robert Levenson

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

We have used in situ hybridization to analyze Na,K-ATPase α and β subunit gene expression during zebrafish embryogenesis. The most striking finding is that each of the 14 Na,K-ATPase genes exhibits a distinct expression profile. All α and β subunit genes are expressed in the nervous system, although the pattern of expression in different regions varies dramatically. In peripheral tissues, three of the five α1-like genes are expressed in pronephros and mucous cells, one is expressed in heart, and one is predominant in skeletal muscle. The α2 gene is expressed in brain and heart but is most prominent in skeletal muscle, while the two α3 genes are restricted in their expression to the nervous system. Of the six β subunit genes, β1a is expressed at highest abundance in lens, pronephros, and heart, while β1b transcripts are abundant in mucous cells. The two β2-like genes are differentially expressed in the nervous system. One β3 gene is expressed exclusively in brain while the other is abundantly expressed in skeletal muscle. Based on these expression patterns, we predict that at least 14 α/β subunit pairs are likely to be formed in different tissues.

Original languageEnglish (US)
Pages (from-to)51-59
Number of pages9
JournalMechanisms of Development
Volume116
Issue number1-2
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

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