Naltrexone modulates growth in infant rats

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Naltrexone, a potent opiate antagonist, had both stimulatory and inhibitory effects on somatic growth in preweaning rats depending on dose. Daily injections of 50 mg/kg naltrexone, which blocked morphine-induced analgesia for 24 hr/day, resulted in increased body and organ weights, and acceleration in the appearance of physical characteristics and maturation of spontaneous motor activity. Naltrexone in a dosage of 1 mg/kg, which blocked morphine-induced analgesia for 4 hr/day, had the opposite effects. These results show that naltrexone can modulate growth, and suggest a role for the endorphins and opiate receptors in developmental events.

Original languageEnglish (US)
Pages (from-to)2449-2454
Number of pages6
JournalLife Sciences
Volume33
Issue number24
DOIs
StatePublished - Dec 12 1983

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Naltrexone
Rats
Opioid Receptors
Growth
Analgesia
Morphine
Opiate Alkaloids
Organ Size
Motor Activity
Body Weight
Injections

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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Naltrexone modulates growth in infant rats. / Zagon, Ian S.; McLaughlin, Patricia J.

In: Life Sciences, Vol. 33, No. 24, 12.12.1983, p. 2449-2454.

Research output: Contribution to journalArticle

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