Nanodisco balls: Control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles

Peter Chhour, Nicolas Gallo, Rabee Cheheltani, Dewight Williams, Ajlan Al-Zaki, Taejong Paik, Jessica L. Nichol, Zhicheng Tian, Pratap C. Naha, Walter R. Witschey, Harry R. Allcock, Christopher B. Murray, Andrew Tsourkas, David P. Cormode

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Nanoparticles of complex architectures can have unique properties. Self-assembly of spherical nanocrystals is a high yielding route to such systems. In this study, we report the self-assembly of a polymer and nanocrystals into aggregates, where the location of the nanocrystals can be controlled to be either at the surface or in the core. These nanospheres, when surface decorated with nanocrystals, resemble disco balls, thus the term nanodisco balls. We studied the mechanism of this surface loading phenomenon and found it to be Ca2+ dependent. We also investigated whether excess phospholipids could prevent nanocrystal adherence. We found surface loading to occur with a variety of nanocrystal types including iron oxide nanoparticles, quantum dots, and nanophosphors, as well as sizes (10-30 nm) and shapes. Additionally, surface loading occurred over a range of polymer molecular weights (∼30-3000 kDa) and phospholipid carbon tail length. We also show that nanocrystals remain diagnostically active after loading onto the polymer nanospheres, i.e., providing contrast in the case of magnetic resonance imaging for iron oxide nanoparticles and fluorescence for quantum dots. Last, we demonstrated that a fluorescently labeled protein model drug can be delivered by surface loaded nanospheres. We present a platform for contrast media delivery, with the unusual feature that the payload can be controllably localized to the core or the surface.

Original languageEnglish (US)
Pages (from-to)9143-9153
Number of pages11
JournalACS Nano
Volume8
Issue number9
DOIs
StatePublished - Sep 23 2014

Fingerprint

Nanocrystals
balls
nanocrystals
Polymers
Nanoparticles
nanoparticles
polymers
Nanospheres
Phospholipids
Iron oxides
iron oxides
Self assembly
Semiconductor quantum dots
self assembly
quantum dots
Contrast media
Magnetic resonance
payloads
Contrast Media
magnetic resonance

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Chhour, P., Gallo, N., Cheheltani, R., Williams, D., Al-Zaki, A., Paik, T., ... Cormode, D. P. (2014). Nanodisco balls: Control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles. ACS Nano, 8(9), 9143-9153. https://doi.org/10.1021/nn502730q
Chhour, Peter ; Gallo, Nicolas ; Cheheltani, Rabee ; Williams, Dewight ; Al-Zaki, Ajlan ; Paik, Taejong ; Nichol, Jessica L. ; Tian, Zhicheng ; Naha, Pratap C. ; Witschey, Walter R. ; Allcock, Harry R. ; Murray, Christopher B. ; Tsourkas, Andrew ; Cormode, David P. / Nanodisco balls : Control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles. In: ACS Nano. 2014 ; Vol. 8, No. 9. pp. 9143-9153.
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Chhour, P, Gallo, N, Cheheltani, R, Williams, D, Al-Zaki, A, Paik, T, Nichol, JL, Tian, Z, Naha, PC, Witschey, WR, Allcock, HR, Murray, CB, Tsourkas, A & Cormode, DP 2014, 'Nanodisco balls: Control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles', ACS Nano, vol. 8, no. 9, pp. 9143-9153. https://doi.org/10.1021/nn502730q

Nanodisco balls : Control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles. / Chhour, Peter; Gallo, Nicolas; Cheheltani, Rabee; Williams, Dewight; Al-Zaki, Ajlan; Paik, Taejong; Nichol, Jessica L.; Tian, Zhicheng; Naha, Pratap C.; Witschey, Walter R.; Allcock, Harry R.; Murray, Christopher B.; Tsourkas, Andrew; Cormode, David P.

In: ACS Nano, Vol. 8, No. 9, 23.09.2014, p. 9143-9153.

Research output: Contribution to journalArticle

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T1 - Nanodisco balls

T2 - Control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles

AU - Chhour, Peter

AU - Gallo, Nicolas

AU - Cheheltani, Rabee

AU - Williams, Dewight

AU - Al-Zaki, Ajlan

AU - Paik, Taejong

AU - Nichol, Jessica L.

AU - Tian, Zhicheng

AU - Naha, Pratap C.

AU - Witschey, Walter R.

AU - Allcock, Harry R.

AU - Murray, Christopher B.

AU - Tsourkas, Andrew

AU - Cormode, David P.

PY - 2014/9/23

Y1 - 2014/9/23

N2 - Nanoparticles of complex architectures can have unique properties. Self-assembly of spherical nanocrystals is a high yielding route to such systems. In this study, we report the self-assembly of a polymer and nanocrystals into aggregates, where the location of the nanocrystals can be controlled to be either at the surface or in the core. These nanospheres, when surface decorated with nanocrystals, resemble disco balls, thus the term nanodisco balls. We studied the mechanism of this surface loading phenomenon and found it to be Ca2+ dependent. We also investigated whether excess phospholipids could prevent nanocrystal adherence. We found surface loading to occur with a variety of nanocrystal types including iron oxide nanoparticles, quantum dots, and nanophosphors, as well as sizes (10-30 nm) and shapes. Additionally, surface loading occurred over a range of polymer molecular weights (∼30-3000 kDa) and phospholipid carbon tail length. We also show that nanocrystals remain diagnostically active after loading onto the polymer nanospheres, i.e., providing contrast in the case of magnetic resonance imaging for iron oxide nanoparticles and fluorescence for quantum dots. Last, we demonstrated that a fluorescently labeled protein model drug can be delivered by surface loaded nanospheres. We present a platform for contrast media delivery, with the unusual feature that the payload can be controllably localized to the core or the surface.

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