Nanofibers as Bioinstructive Scaffolds Capable of Modulating Differentiation Through Mechanosensitive Pathways for Regenerative Engineering

Daniel T. Bowers, Justin L. Brown

Research output: Contribution to journalReview article

Abstract

Bioinstructive scaffolds encode information in the physical shape and size of materials to direct cell responses. Electrospinning of nanofibers is a process that offers control over scaffold architecture and fiber diameter, while providing extended linear length of fibers. This review summarizes tissue engineering literature that has utilized nanofiber scaffolds to direct stem cell differentiation for various tissues including the musculoskeletal, vascular, immunological, and nervous system tissues. Nanofibers are also considered for their extracellular matrix mimetic characteristics that can preserve stem cell differentiation capacity. These topics are considered in the context of focal adhesion and integrin signaling. Regenerative engineering will be enhanced by construction of scaffolds encoded with shape information to cause an attached cell to create the intended tissue at that region. Nanofibers are likely to be a bioinstructive scaffold in future regenerative engineering development as we pursue the Grand Challenges of engineering tissues.

Original languageEnglish (US)
Pages (from-to)22-29
Number of pages8
JournalRegenerative Engineering and Translational Medicine
Volume5
Issue number1
DOIs
StatePublished - Mar 15 2019

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Nanofibers
Scaffolds
Tissue Engineering
Tissue
Stem cells
Tissue engineering
Cell Differentiation
Stem Cells
Nerve Tissue
Focal Adhesions
Fibers
Electrospinning
Neurology
Scaffolds (biology)
Integrins
Nervous System
Extracellular Matrix
Blood Vessels
Adhesion

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cell Biology

Cite this

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