Nanogel carrier for intracellular delivery of quantum dot

Urara Hasegawa, Kazunari Akiyoshi

Research output: Contribution to conferencePaperpeer-review

Abstract

We report here a novel carrier for intracellular delivery of quantum dots (QDs). Monodisperse hybrid nanoparticles (38 nm in diameter) were prepared by simple mixing of quantum dots and nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH 2). These nanoparticles were immediately adsorbed on to cell surface and effectively internalized into cells. The efficiency of cellular uptake was much higher than that of cationic liposome. In additon, the internalization of QDs with cells was controlled by the amino-group content of CHPNH 2 nanogel. These hybrid nanoparticles could be utilized as a novel fluorescent probe for bioimaging.

Original languageEnglish (US)
Pages4957-4958
Number of pages2
StatePublished - 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005

Conference

Conference54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period9/20/059/22/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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