Nanoparticle-based protein detection by optical shift of a resonant microcavity

Miguel A. Santiago-Cordoba, Svetlana V. Boriskina, Frank Vollmer, Melik C. Demirel

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

We demonstrated a biosensing approach which, for the first time, combines the high sensitivity of whispering gallery modes (WGMs) with a metallic nanoparticle-based assay. We provided a computational model based on generalized Mie theory to explain the higher sensitivity of protein detection. We quantitatively analyzed the binding of a model protein (i.e., Bovine Serum Albumin) to gold nanoparticles from high-Q WGM resonance frequency shifts, and fit the results to an adsorption isotherm, which agrees with the theoretical predictions of a two-component adsorption model.

Original languageEnglish (US)
Article number073701
JournalApplied Physics Letters
Volume99
Issue number7
DOIs
StatePublished - Aug 15 2011

Fingerprint

whispering gallery modes
proteins
nanoparticles
shift
adsorption
sensitivity
Mie scattering
albumins
serums
frequency shift
Q factors
isotherms
gold
predictions

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

Cite this

Santiago-Cordoba, Miguel A. ; Boriskina, Svetlana V. ; Vollmer, Frank ; Demirel, Melik C. / Nanoparticle-based protein detection by optical shift of a resonant microcavity. In: Applied Physics Letters. 2011 ; Vol. 99, No. 7.
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Nanoparticle-based protein detection by optical shift of a resonant microcavity. / Santiago-Cordoba, Miguel A.; Boriskina, Svetlana V.; Vollmer, Frank; Demirel, Melik C.

In: Applied Physics Letters, Vol. 99, No. 7, 073701, 15.08.2011.

Research output: Contribution to journalArticle

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