Narcolepsy/cataplexy. IV: Diagnostic value of daytime nap recordings

A. Kales, E. O. Bixler, C. R. Soldatos, R. J. Cadieux, R. Manfredi, A. Vela‐Bueno

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ABSTRACT— Sleep and wakefulness patterns in daytime naps of 50 patients with narcolepsy/cataplexy were compared with those of 50 controls. Each subject was monitored polygraphically during 2 one‐hour nap periods. A sleep‐onset REM period in either of the 2 daytime naps was observed to have a higher diagnostic sensitivity (78%) than an abnormally shortened sleep latency (68%). However, the specificities of a sleep‐onset REM period (88%) of abnormally shortened sleep latency (90%) were quite similar. When the occurrence of either a sleep‐onset REM period or a shortened sleep latency was evaluated in either of the two naps, the overall sensitivity was increased to 84% while the specificity was decreased only to 80%. The limitations of and indications for the use of testing for sleep and REM latencies in the diagnosis of narcolepsy in clinical practice are discussed.

Original languageEnglish (US)
Pages (from-to)223-230
Number of pages8
JournalActa Neurologica Scandinavica
Issue number4
StatePublished - Apr 1987

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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    Kales, A., Bixler, E. O., Soldatos, C. R., Cadieux, R. J., Manfredi, R., & Vela‐Bueno, A. (1987). Narcolepsy/cataplexy. IV: Diagnostic value of daytime nap recordings. Acta Neurologica Scandinavica, 75(4), 223-230.