Narcotic blockade, length of addiction, and persistence of intravenous morphine self-administration in rats

Gilbert Carnathan, Roger E. Meyer, Joseph Cochin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Four groups of rats differing in the number of periods of prior exposure to morphine sulphate in the i.v. self-administration paradigm were studied under conditions of narcotic blockade. Three groups of subjects also differing in the amount of prior exposure to morphine sulphate were studied under saline conditions. At effective blocking doses of naloxone, opioid-seeking behavior was eliminated in relatively drug naive animals, whereas the persistence of secondary reinforcers in rats with longer addiction histories served to maintain opioid consumption in the presence of adequate pharmacological blockade. Data from saline-treated animals were very similar to data obtained in naloxone-treated animals. The authors conclude that at adequate blocking doses of narcotic antagonist the length of addiction appears to be the best predictor of opioid consumption.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
JournalPsychopharmacology
Volume54
Issue number1
DOIs
StatePublished - Jan 1 1977

Fingerprint

Self Administration
Narcotics
Morphine
Opioid Analgesics
Naloxone
Narcotic Antagonists
Pharmacology
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Carnathan, Gilbert ; Meyer, Roger E. ; Cochin, Joseph. / Narcotic blockade, length of addiction, and persistence of intravenous morphine self-administration in rats. In: Psychopharmacology. 1977 ; Vol. 54, No. 1. pp. 67-71.
@article{80a9b2ded7554a89b0ab224cc5df8c40,
title = "Narcotic blockade, length of addiction, and persistence of intravenous morphine self-administration in rats",
abstract = "Four groups of rats differing in the number of periods of prior exposure to morphine sulphate in the i.v. self-administration paradigm were studied under conditions of narcotic blockade. Three groups of subjects also differing in the amount of prior exposure to morphine sulphate were studied under saline conditions. At effective blocking doses of naloxone, opioid-seeking behavior was eliminated in relatively drug naive animals, whereas the persistence of secondary reinforcers in rats with longer addiction histories served to maintain opioid consumption in the presence of adequate pharmacological blockade. Data from saline-treated animals were very similar to data obtained in naloxone-treated animals. The authors conclude that at adequate blocking doses of narcotic antagonist the length of addiction appears to be the best predictor of opioid consumption.",
author = "Gilbert Carnathan and Meyer, {Roger E.} and Joseph Cochin",
year = "1977",
month = "1",
day = "1",
doi = "10.1007/BF00426544",
language = "English (US)",
volume = "54",
pages = "67--71",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "1",

}

Narcotic blockade, length of addiction, and persistence of intravenous morphine self-administration in rats. / Carnathan, Gilbert; Meyer, Roger E.; Cochin, Joseph.

In: Psychopharmacology, Vol. 54, No. 1, 01.01.1977, p. 67-71.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Narcotic blockade, length of addiction, and persistence of intravenous morphine self-administration in rats

AU - Carnathan, Gilbert

AU - Meyer, Roger E.

AU - Cochin, Joseph

PY - 1977/1/1

Y1 - 1977/1/1

N2 - Four groups of rats differing in the number of periods of prior exposure to morphine sulphate in the i.v. self-administration paradigm were studied under conditions of narcotic blockade. Three groups of subjects also differing in the amount of prior exposure to morphine sulphate were studied under saline conditions. At effective blocking doses of naloxone, opioid-seeking behavior was eliminated in relatively drug naive animals, whereas the persistence of secondary reinforcers in rats with longer addiction histories served to maintain opioid consumption in the presence of adequate pharmacological blockade. Data from saline-treated animals were very similar to data obtained in naloxone-treated animals. The authors conclude that at adequate blocking doses of narcotic antagonist the length of addiction appears to be the best predictor of opioid consumption.

AB - Four groups of rats differing in the number of periods of prior exposure to morphine sulphate in the i.v. self-administration paradigm were studied under conditions of narcotic blockade. Three groups of subjects also differing in the amount of prior exposure to morphine sulphate were studied under saline conditions. At effective blocking doses of naloxone, opioid-seeking behavior was eliminated in relatively drug naive animals, whereas the persistence of secondary reinforcers in rats with longer addiction histories served to maintain opioid consumption in the presence of adequate pharmacological blockade. Data from saline-treated animals were very similar to data obtained in naloxone-treated animals. The authors conclude that at adequate blocking doses of narcotic antagonist the length of addiction appears to be the best predictor of opioid consumption.

UR - http://www.scopus.com/inward/record.url?scp=0017741118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017741118&partnerID=8YFLogxK

U2 - 10.1007/BF00426544

DO - 10.1007/BF00426544

M3 - Article

C2 - 410062

AN - SCOPUS:0017741118

VL - 54

SP - 67

EP - 71

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 1

ER -