Narrowly confined and glomerulus-specific onset latencies of odor-evoked calcium transients in the juxtaglomerular cells of the mouse main olfactory bulb

Ryota Homma, Xiaohua Lv, Tokiharu Sato, Fumiaki Imamura, Shaoqun Zeng, Shin Nagayama

Research output: Contribution to journalArticle

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Abstract

Odor information is transmitted from olfactory sensory neurons to principal neurons at the glomeruli of the olfactory bulb. The intraglomerular neuronal circuit also includes hundreds of interneurons referred to as juxtaglomerular (JG) cells. Stimulus selectivity is well correlated among many JG cells that are associated with the same glomerulus, consistent with their highly homogeneous sensory inputs. However, much less is known about the temporal aspects of their activity, including the temporal coordination of their odor-evoked responses. As many JG cells within a glomerular module respond to the same stimulus, the extent to which their activity is temporally aligned will affect the temporal profile of their population inhibitory inputs. Using random-access high-speed two-photon microscopy, we recorded the odor-evoked calcium transients of mouse JG cells and compared the onset latency and rise time among neurons putatively associated with the same and different glomeruli. Whereas the overall onset latencies of odorevoked transients were distributed across a ~150 ms time window, those from cells putatively associated with the same glomerulus were confined to a much narrower window of several tens of milliseconds. This result suggests that onset latency primarily depends on the associated glomerulus. We also observed glomerular specificity in the rise time. The glomerulus-specific temporal pattern of odor-evoked activity implies that the temporal patterns of inputs from the intraglomerular circuit are unique to individual glomerulusodor pairs, which may contribute to efficient shaping of the temporal pattern of activity in the principal neurons.

Original languageEnglish (US)
Article numbere0387-18.2019
JournaleNeuro
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2019

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Olfactory Bulb
Calcium
Neurons
Olfactory Receptor Neurons
Odorants
Interneurons
Photons
Microscopy

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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title = "Narrowly confined and glomerulus-specific onset latencies of odor-evoked calcium transients in the juxtaglomerular cells of the mouse main olfactory bulb",
abstract = "Odor information is transmitted from olfactory sensory neurons to principal neurons at the glomeruli of the olfactory bulb. The intraglomerular neuronal circuit also includes hundreds of interneurons referred to as juxtaglomerular (JG) cells. Stimulus selectivity is well correlated among many JG cells that are associated with the same glomerulus, consistent with their highly homogeneous sensory inputs. However, much less is known about the temporal aspects of their activity, including the temporal coordination of their odor-evoked responses. As many JG cells within a glomerular module respond to the same stimulus, the extent to which their activity is temporally aligned will affect the temporal profile of their population inhibitory inputs. Using random-access high-speed two-photon microscopy, we recorded the odor-evoked calcium transients of mouse JG cells and compared the onset latency and rise time among neurons putatively associated with the same and different glomeruli. Whereas the overall onset latencies of odorevoked transients were distributed across a ~150 ms time window, those from cells putatively associated with the same glomerulus were confined to a much narrower window of several tens of milliseconds. This result suggests that onset latency primarily depends on the associated glomerulus. We also observed glomerular specificity in the rise time. The glomerulus-specific temporal pattern of odor-evoked activity implies that the temporal patterns of inputs from the intraglomerular circuit are unique to individual glomerulusodor pairs, which may contribute to efficient shaping of the temporal pattern of activity in the principal neurons.",
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Narrowly confined and glomerulus-specific onset latencies of odor-evoked calcium transients in the juxtaglomerular cells of the mouse main olfactory bulb. / Homma, Ryota; Lv, Xiaohua; Sato, Tokiharu; Imamura, Fumiaki; Zeng, Shaoqun; Nagayama, Shin.

In: eNeuro, Vol. 6, No. 1, e0387-18.2019, 01.01.2019.

Research output: Contribution to journalArticle

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T1 - Narrowly confined and glomerulus-specific onset latencies of odor-evoked calcium transients in the juxtaglomerular cells of the mouse main olfactory bulb

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AU - Lv, Xiaohua

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AU - Zeng, Shaoqun

AU - Nagayama, Shin

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