TY - JOUR
T1 - Natural and TGF-β-induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other
AU - Horwitz, David A.
AU - Zheng, Song Guo
AU - Gray, J. Dixon
PY - 2008/9/1
Y1 - 2008/9/1
N2 - Foxp3+ CD4+ CD25+ regulatory cell (Treg) subsets that maintain immunologic homeostasis have been considered to be a homogeneous population of naturally occurring, thymus-derived CD4+CD25+ cells (nTregs). However, similar Foxp3+ Tregs can be induced from CD25- precursors in vivo, and ex vivo with interleukin 2 (IL-2) and transforming growth factor β (TGF-β) (iTregs). These two subsets differ in their principal antigen specificities and in the T-cell receptor signal strength and co-stimulatory requirements needed for their generation. However, whether iTregs have any unique functions in vivo has been unclear. Although IL-6 can convert nTregs to Th17 cells, iTregs induced by IL-2 and TGF-β are resistant to this cytokine and thereby might retain suppressive function at inflammatory sites. Thus, nTregs and iTregs may have different roles in the adaptive immune response.
AB - Foxp3+ CD4+ CD25+ regulatory cell (Treg) subsets that maintain immunologic homeostasis have been considered to be a homogeneous population of naturally occurring, thymus-derived CD4+CD25+ cells (nTregs). However, similar Foxp3+ Tregs can be induced from CD25- precursors in vivo, and ex vivo with interleukin 2 (IL-2) and transforming growth factor β (TGF-β) (iTregs). These two subsets differ in their principal antigen specificities and in the T-cell receptor signal strength and co-stimulatory requirements needed for their generation. However, whether iTregs have any unique functions in vivo has been unclear. Although IL-6 can convert nTregs to Th17 cells, iTregs induced by IL-2 and TGF-β are resistant to this cytokine and thereby might retain suppressive function at inflammatory sites. Thus, nTregs and iTregs may have different roles in the adaptive immune response.
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U2 - 10.1016/j.it.2008.06.005
DO - 10.1016/j.it.2008.06.005
M3 - Review article
C2 - 18676178
AN - SCOPUS:49849094011
VL - 29
SP - 429
EP - 435
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 9
ER -