Naturally elicited antibodies to glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum require intact GPI structures for binding and are directed primarily against the conserved glycan moiety

Ramachandra S. Naik, Gowdahalli Krishnegowda, Christian F. Ockenhouse, D. Channe Gowda

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Immunization with a synthetic glycan corresponding to Plasmodium falciparum glycosylphosphatidylinositols (GPIs) has been proposed as a vaccination strategy against malaria. We investigated the structural requirements for binding of naturally elicited anti-GPI antibodies to parasite GPIs. The data show that anti-GPI antibody binding requires intact GPI structures and that the antibodies are directed predominantly against GPIs with a conserved glycan structure with three mannoses and marginally against the terminal fourth mannose. The results provide valuable insight for exploiting GPIs for the development of malaria vaccines.

Original languageEnglish (US)
Pages (from-to)1412-1415
Number of pages4
JournalInfection and Immunity
Volume74
Issue number2
DOIs
Publication statusPublished - Feb 1 2006

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this