Near infrared (NIR) strong field ionization and imaging of C60 sputtered molecules

Overcoming matrix effects and improving sensitivity

Andrew Kucher, Lauren M. Jackson, Jordan Oswald Lerach, A. N. Bloom, N. J. Popczun, Andreas Wucher, Nicholas Winograd

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Strong field ionization (SFI) was applied for the secondary neutral mass spectrometry (SNMS) of patterned rubrene films, mouse brain sections, and Botryococcus braunii algal cell colonies. Molecular ions of rubrene, cholesterol, C31 diene/triene, and three wax monoesters were detected, representing some of the largest organic molecules ever ionized intact by a laser post-ionization experiment. In rubrene, the SFI SNMS molecular ion signal was ∼4 times higher than in the corresponding secondary-ion mass spectroscopy (SIMS) analysis. In the biological samples, the achieved signal improvements varied among molecules and sampling locations, with SFI SNMS, in some cases, revealing analytes made completely undetectable by the influence of matrix effects in SIMS.

Original languageEnglish (US)
Pages (from-to)8613-8620
Number of pages8
JournalAnalytical Chemistry
Volume86
Issue number17
DOIs
StatePublished - Sep 2 2014

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Ionization
Ions
Infrared radiation
Mass spectrometry
Imaging techniques
Molecules
Spectroscopy
Waxes
Brain
Cholesterol
Sampling
Lasers
rubrene
Experiments

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Cite this

Kucher, Andrew ; Jackson, Lauren M. ; Lerach, Jordan Oswald ; Bloom, A. N. ; Popczun, N. J. ; Wucher, Andreas ; Winograd, Nicholas. / Near infrared (NIR) strong field ionization and imaging of C60 sputtered molecules : Overcoming matrix effects and improving sensitivity. In: Analytical Chemistry. 2014 ; Vol. 86, No. 17. pp. 8613-8620.
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Near infrared (NIR) strong field ionization and imaging of C60 sputtered molecules : Overcoming matrix effects and improving sensitivity. / Kucher, Andrew; Jackson, Lauren M.; Lerach, Jordan Oswald; Bloom, A. N.; Popczun, N. J.; Wucher, Andreas; Winograd, Nicholas.

In: Analytical Chemistry, Vol. 86, No. 17, 02.09.2014, p. 8613-8620.

Research output: Contribution to journalArticle

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AU - Kucher, Andrew

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AU - Winograd, Nicholas

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