Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy

Mao Bin Meng, Huan Huan Wang, Yao Li Cui, Zhi Qiang Wu, Yang Yang Shi, Nicholas G. Zaorsky, Lei Deng, Zhi Yong Yuan, You Lu, Ping Wang

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

While the mechanisms underlying apoptosis and autophagy have been well characterized over recent decades, another regulated cell death event, necroptosis, remains poorly understood. Elucidating the signaling networks involved in the regulation of necroptosis may allow this form of regulated cell death to be exploited for diagnosis and treatment of cancer, and will contribute to the understanding of the complex tumor microenvironment. In this review, we have summarized the mechanisms and regulation of necroptosis, the converging and diverging features of necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy, as well as attempts to exploit this newly gained knowledge to provide therapeutics for cancer.

Original languageEnglish (US)
Pages (from-to)57391-57413
Number of pages23
JournalOncotarget
Volume7
Issue number35
DOIs
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Oncology

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