Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy

Mao Bin Meng, Huan Huan Wang, Yao Li Cui, Zhi Qiang Wu, Yang Yang Shi, Nicholas G. Zaorsky, Lei Deng, Zhi Yong Yuan, You Lu, Ping Wang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

While the mechanisms underlying apoptosis and autophagy have been well characterized over recent decades, another regulated cell death event, necroptosis, remains poorly understood. Elucidating the signaling networks involved in the regulation of necroptosis may allow this form of regulated cell death to be exploited for diagnosis and treatment of cancer, and will contribute to the understanding of the complex tumor microenvironment. In this review, we have summarized the mechanisms and regulation of necroptosis, the converging and diverging features of necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy, as well as attempts to exploit this newly gained knowledge to provide therapeutics for cancer.

Original languageEnglish (US)
Pages (from-to)57391-57413
Number of pages23
JournalOncotarget
Volume7
Issue number35
DOIs
StatePublished - Jan 1 2016

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Immunity
Carcinogenesis
Neoplasms
Cell Death
Tumor Microenvironment
Autophagy
Therapeutics
Apoptosis

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Meng, M. B., Wang, H. H., Cui, Y. L., Wu, Z. Q., Shi, Y. Y., Zaorsky, N. G., ... Wang, P. (2016). Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. Oncotarget, 7(35), 57391-57413. https://doi.org/10.18632/oncotarget.10548
Meng, Mao Bin ; Wang, Huan Huan ; Cui, Yao Li ; Wu, Zhi Qiang ; Shi, Yang Yang ; Zaorsky, Nicholas G. ; Deng, Lei ; Yuan, Zhi Yong ; Lu, You ; Wang, Ping. / Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. In: Oncotarget. 2016 ; Vol. 7, No. 35. pp. 57391-57413.
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Meng, MB, Wang, HH, Cui, YL, Wu, ZQ, Shi, YY, Zaorsky, NG, Deng, L, Yuan, ZY, Lu, Y & Wang, P 2016, 'Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy', Oncotarget, vol. 7, no. 35, pp. 57391-57413. https://doi.org/10.18632/oncotarget.10548

Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. / Meng, Mao Bin; Wang, Huan Huan; Cui, Yao Li; Wu, Zhi Qiang; Shi, Yang Yang; Zaorsky, Nicholas G.; Deng, Lei; Yuan, Zhi Yong; Lu, You; Wang, Ping.

In: Oncotarget, Vol. 7, No. 35, 01.01.2016, p. 57391-57413.

Research output: Contribution to journalArticle

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