Needs and opportunities for research in hypersensitivity pneumonitis

Jordan N. Fink, Hector G. Ortega, Herbert Reynolds, Yvon F. Cormier, Leland L. Fan, Terl J. Franks, Kathleen Kreiss, Steven Kunkel, David Lynch, Santiago Quirce, Cecile Rose, Robert P. Schleimer, Mark R. Schuyler, Moises Selman, Douglas Trout, Yasuyuki Yoshizawa

Research output: Contribution to journalReview articlepeer-review

149 Scopus citations

Abstract

Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to improve detection and diagnosis are needed, and treatment options, principally avoidance, are limited. A workshop recommended: a population-based study to more accurately document the incidence and prevalence of HP; better classification of disease stages, including natural history; evaluation of diagnostic tests and biomarkers used to detect disease; better correlation of computerized tomography lung imaging and pathologic changes; more study of inflammatory and immune mechanisms; and improvement of animal models that are more relevant for human disease.

Original languageEnglish (US)
Pages (from-to)792-798
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume171
Issue number7
DOIs
StatePublished - Apr 1 2005

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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