Abstract
Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 609-620 |
| Number of pages | 12 |
| Journal | Cell |
| Volume | 70 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 21 1992 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
}
Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. / Lai, Zhi Chun; Rubin, Gerald M.
In: Cell, Vol. 70, No. 4, 21.08.1992, p. 609-620.Research output: Contribution to journal › Article
TY - JOUR
T1 - Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein
AU - Lai, Zhi Chun
AU - Rubin, Gerald M.
PY - 1992/8/21
Y1 - 1992/8/21
N2 - Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.
AB - Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.
UR - http://www.scopus.com/inward/record.url?scp=0026723089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026723089&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(92)90430-K
DO - 10.1016/0092-8674(92)90430-K
M3 - Article
C2 - 1505027
AN - SCOPUS:0026723089
VL - 70
SP - 609
EP - 620
JO - Cell
JF - Cell
SN - 0092-8674
IS - 4
ER -