Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

Zhi Chun Lai, Gerald M. Rubin

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.

Original languageEnglish (US)
Pages (from-to)609-620
Number of pages12
JournalCell
Volume70
Issue number4
DOIs
StatePublished - Aug 21 1992

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Drosophila
Genes
Cell Nucleus
Cones
Proteins
Mutation
DNA
ETS Motif

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. / Lai, Zhi Chun; Rubin, Gerald M.

In: Cell, Vol. 70, No. 4, 21.08.1992, p. 609-620.

Research output: Contribution to journalArticle

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