Abstract
Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 609-620 |
| Number of pages | 12 |
| Journal | Cell |
| Volume | 70 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 21 1992 |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Lai, Z. C., & Rubin, G. M. (1992). Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell, 70(4), 609-620. https://doi.org/10.1016/0092-8674(92)90430-K