Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription

Malini Natarajan, Gillian M. Schiralli Lester, Chanhyo Lee, Anamika Missra, Gregory A. Wasserman, Martin Steffen, David S. Gilmour, Andrew J. Henderson

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Background: Multiple mechanisms contribute to HIV latency, including NELF-mediated RNA polymerase II (RNAP II) pausing. Results: Paused RNAP II recruits a transcription termination factor and a transcriptional corepressor complex to the HIV promoter. Conclusion: PausedRNAPII couples premature transcription termination and chromatin remodeling to maintain HIV latency. Significance: Paused RNAP II may be targeted to purge latent HIV infection.

Original languageEnglish (US)
Pages (from-to)25995-26003
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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