Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4 + Foxp3 + Regulatory T Cells

Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy Olsen, Song Guo Zheng

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered.

Original languageEnglish (US)
Pages (from-to)1869-1879.e3
JournalCell Reports
Volume26
Issue number7
DOIs
StatePublished - Feb 12 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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