Neonatal tolerance induction across regions of H-2 complex

J. W. Streilein, Jan Klein

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37 Scopus citations


Regions of the H-2 complex were evaluated for their capacity to resist neonatal tolerance induction. Congenic recombinant strains and mutants were employed to study K, I, and D region disparity. It was found that tolerance could be induced to differences at each region; however, the K region of the H-2 complex is not only highly immunogenic, but markedly resistant to neonatal tolerance induction. This is especially apparent when the host is derived from B10 stocks, even though the MHC haplotypes involved are not H-2(b) indicating that genetic factors unlinked to the MHC clearly play an important role in determining the ease of neontal tolerance induction.

Original languageEnglish (US)
Pages (from-to)2147-2150
Number of pages4
JournalJournal of Immunology
Issue number6
StatePublished - Dec 1 1977

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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