Neonatal tolerance of H-2 alloantigens. I. I region modulation of tolerogenic potential of K and D antigens

J. W. Streilein, J. Klein

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

By utilizing H-2 congenic strains of mice and appropriate recombinants, it has been possible to determine that Class I alloantigens (of K and D region genes) function poorly as tolerogens when inoculated into neonatal recipients. Alternatively, Class II alloantigens (encoded by I region genes) are excellent tolerogens. Moreover, Class I alloantigens are converted to good tolerogens when conjoined in the tolerizing inoculum with Class II alloantigens. The I subregions in which genes reside that mediate this tolerance-promoting effect are IJ and/or IE. It is suggested that elicitation of a suppressor mechanism, perhaps related to IJ region alloantigens, is responsible.

Original languageEnglish (US)
Pages (from-to)461-474
Number of pages14
JournalProceedings of the Royal Society of London - Biological Sciences
Volume207
Issue number1169
DOIs
StatePublished - Jan 1 1980

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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