Nephrogenic systemic fibrosis among liver transplant recipients: A single institution experience and topic update

M. Maloo, P. Abt, R. Kashyap, D. Younan, M. Zand, M. Orloff, A. Jain, A. Pentland, G. Scott, A. Bozorgzadeh

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Nephrogenic systemic fibrosis (NSF) is a recently characterized systemic fibrosing disorder developing in the setting of renal insufficiency. NSF's rapidly progressive nature resulting in disability within weeks of onset makes early diagnosis important. Two reports of NSF after liver transplantation are known of. We present three cases of NSF developing within a few months after liver transplantation and review the current literature. Loss of regulatory control of the circulating fibrocyte, its aberrant recruitment, in a milieu of renal failure and a recent vascular procedure appear important in its development. Known current therapies lack consistent efficacy. Only an improvement in renal function has the greatest likelihood of NSF's resolution. Delayed recognition may pose a significant barrier to functional recovery in the ubiquitously deconditioned liver transplant patient. Early recognition and implementation of aggressive physical therapy appear to have the greatest impact on halting its progression.

Original languageEnglish (US)
Pages (from-to)2212-2217
Number of pages6
JournalAmerican Journal of Transplantation
Volume6
Issue number9
DOIs
StatePublished - Sep 1 2006

Fingerprint

Nephrogenic Fibrosing Dermopathy
Liver Transplantation
Renal Insufficiency
Liver
Blood Vessels
Early Diagnosis
Transplants
Kidney
Therapeutics
Transplant Recipients

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Maloo, M. ; Abt, P. ; Kashyap, R. ; Younan, D. ; Zand, M. ; Orloff, M. ; Jain, A. ; Pentland, A. ; Scott, G. ; Bozorgzadeh, A. / Nephrogenic systemic fibrosis among liver transplant recipients : A single institution experience and topic update. In: American Journal of Transplantation. 2006 ; Vol. 6, No. 9. pp. 2212-2217.
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Maloo, M, Abt, P, Kashyap, R, Younan, D, Zand, M, Orloff, M, Jain, A, Pentland, A, Scott, G & Bozorgzadeh, A 2006, 'Nephrogenic systemic fibrosis among liver transplant recipients: A single institution experience and topic update', American Journal of Transplantation, vol. 6, no. 9, pp. 2212-2217. https://doi.org/10.1111/j.1600-6143.2006.01420.x

Nephrogenic systemic fibrosis among liver transplant recipients : A single institution experience and topic update. / Maloo, M.; Abt, P.; Kashyap, R.; Younan, D.; Zand, M.; Orloff, M.; Jain, A.; Pentland, A.; Scott, G.; Bozorgzadeh, A.

In: American Journal of Transplantation, Vol. 6, No. 9, 01.09.2006, p. 2212-2217.

Research output: Contribution to journalArticle

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AU - Orloff, M.

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