Nested genes and increasing organizational complexity of metazoan genomes

Raquel Assis, Alexey S. Kondrashov, Eugene V. Koonin, Fyodor A. Kondrashov

Research output: Contribution to journalShort survey

28 Citations (Scopus)

Abstract

The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalTrends in Genetics
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2008

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Nested Genes
Genome
Eukaryota
Diptera
Introns
Genes
Vertebrates
Fruit
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Assis, R., Kondrashov, A. S., Koonin, E. V., & Kondrashov, F. A. (2008). Nested genes and increasing organizational complexity of metazoan genomes. Trends in Genetics, 24(10), 475-478. https://doi.org/10.1016/j.tig.2008.08.003
Assis, Raquel ; Kondrashov, Alexey S. ; Koonin, Eugene V. ; Kondrashov, Fyodor A. / Nested genes and increasing organizational complexity of metazoan genomes. In: Trends in Genetics. 2008 ; Vol. 24, No. 10. pp. 475-478.
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Assis, R, Kondrashov, AS, Koonin, EV & Kondrashov, FA 2008, 'Nested genes and increasing organizational complexity of metazoan genomes', Trends in Genetics, vol. 24, no. 10, pp. 475-478. https://doi.org/10.1016/j.tig.2008.08.003

Nested genes and increasing organizational complexity of metazoan genomes. / Assis, Raquel; Kondrashov, Alexey S.; Koonin, Eugene V.; Kondrashov, Fyodor A.

In: Trends in Genetics, Vol. 24, No. 10, 01.10.2008, p. 475-478.

Research output: Contribution to journalShort survey

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